Anti-NTRK2/ TrkB/ EIEE58 monoclonal antibody

Anti-NTRK2/ TrkB/ EIEE58 antibody for FACS & in-vivo assay

Target products collectionGo to TrkB/NTRK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T84703-Ab-1/ GM-Tg-hg-T84703-Ab-2Anti-Human TrkB/NTRK2 monoclonal antibodyHuman
GM-Tg-rg-T84703-Ab-1/ GM-Tg-rg-T84703-Ab-2Anti-Rat TrkB/NTRK2 monoclonal antibodyRat
GM-Tg-mg-T84703-Ab-1/ GM-Tg-mg-T84703-Ab-2Anti-Mouse TrkB/NTRK2 monoclonal antibodyMouse
GM-Tg-cynog-T84703-Ab-1/ GM-Tg-cynog-T84703-Ab-2Anti-Cynomolgus/ Rhesus macaque TrkB/NTRK2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T84703-Ab-1/ GM-Tg-felg-T84703-Ab-2Anti-Feline TrkB/NTRK2 monoclonal antibodyFeline
GM-Tg-cang-T84703-Ab-1/ GM-Tg-cang-T84703-Ab-2Anti-Canine TrkB/NTRK2 monoclonal antibodyCanine
GM-Tg-bovg-T84703-Ab-1/ GM-Tg-bovg-T84703-Ab-2Anti-Bovine TrkB/NTRK2 monoclonal antibodyBovine
GM-Tg-equg-T84703-Ab-1/ GM-Tg-equg-T84703-Ab-2Anti-Equine TrkB/NTRK2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T84703-Ab-1/ GM-Tg-hg-T84703-Ab-2; GM-Tg-rg-T84703-Ab-1/ GM-Tg-rg-T84703-Ab-2;
GM-Tg-mg-T84703-Ab-1/ GM-Tg-mg-T84703-Ab-2; GM-Tg-cynog-T84703-Ab-1/ GM-Tg-cynog-T84703-Ab-2;
GM-Tg-felg-T84703-Ab-1/ GM-Tg-felg-T84703-Ab-2; GM-Tg-cang-T84703-Ab-1/ GM-Tg-cang-T84703-Ab-2;
GM-Tg-bovg-T84703-Ab-1/ GM-Tg-bovg-T84703-Ab-2; GM-Tg-equg-T84703-Ab-1/ GM-Tg-equg-T84703-Ab-2
Products NameAnti-TrkB/NTRK2 monoclonal antibody
Formatmab
Target NameTrkB
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TrkB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species NTRK2/ TrkB/ EIEE58 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000193human NTRK2 Lentivirus particle
    ORF Viral VectorpGMAP000431Human NTRK2 Adenovirus plasmid
    ORF Viral VectorvGMAP000431Human NTRK2 Adenovirus particle
    ORF Viral VectorpGMLV000514human NTRK2 Lentivirus plasmid
    ORF Viral VectorvGMLV000514human NTRK2 Lentivirus particle
    ORF Viral VectorpGMLV000193human NTRK2 Lentivirus plasmid
    ORF Viral VectorpGMLPm004775mouse Ntrk2 Lentivirus plasmid
    ORF Viral VectorvGMLPm004775mouse Ntrk2 Lentivirus particle


    Target information

    Target IDGM-T84703
    Target NameTrkB
    Gene ID4915,18212,25054,709757,484147,101101347,505824,100061700
    Gene Symbol and SynonymsDEE58,EIEE58,GP145-TrkB,GP145-TrkB/GP95-TrkB,NTRK2,OBHD,RATTRKB1,Tkrb,trk-B,TRKB,TRKB1
    Uniprot AccessionQ16620,Q63604
    Uniprot Entry NameNTRK2_HUMAN,NTRK2_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000148053
    Target ClassificationKinase, Tumor-associated antigen (TAA)

    The target: TrkB, gene name: NTRK2, also named as EIEE58, GP145-TrkB, OBHD, TRKB, trk-B. This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.