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Anti-IL31R/ IL31RA/ CRL monoclonal antibody
Anti-IL31R/ IL31RA/ CRL antibody for FACS & in-vivo assay
Go to IL31R/IL31RA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T84614-Ab-1/ GM-Tg-hg-T84614-Ab-2 | Anti-Human IL31R/IL31RA monoclonal antibody | Human |
| GM-Tg-rg-T84614-Ab-1/ GM-Tg-rg-T84614-Ab-2 | Anti-Rat IL31R/IL31RA monoclonal antibody | Rat |
| GM-Tg-mg-T84614-Ab-1/ GM-Tg-mg-T84614-Ab-2 | Anti-Mouse IL31R/IL31RA monoclonal antibody | Mouse |
| GM-Tg-cynog-T84614-Ab-1/ GM-Tg-cynog-T84614-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL31R/IL31RA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T84614-Ab-1/ GM-Tg-felg-T84614-Ab-2 | Anti-Feline IL31R/IL31RA monoclonal antibody | Feline |
| GM-Tg-cang-T84614-Ab-1/ GM-Tg-cang-T84614-Ab-2 | Anti-Canine IL31R/IL31RA monoclonal antibody | Canine |
| GM-Tg-bovg-T84614-Ab-1/ GM-Tg-bovg-T84614-Ab-2 | Anti-Bovine IL31R/IL31RA monoclonal antibody | Bovine |
| GM-Tg-equg-T84614-Ab-1/ GM-Tg-equg-T84614-Ab-2 | Anti-Equine IL31R/IL31RA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T84614-Ab-1/ GM-Tg-hg-T84614-Ab-2; GM-Tg-rg-T84614-Ab-1/ GM-Tg-rg-T84614-Ab-2; GM-Tg-mg-T84614-Ab-1/ GM-Tg-mg-T84614-Ab-2; GM-Tg-cynog-T84614-Ab-1/ GM-Tg-cynog-T84614-Ab-2; GM-Tg-felg-T84614-Ab-1/ GM-Tg-felg-T84614-Ab-2; GM-Tg-cang-T84614-Ab-1/ GM-Tg-cang-T84614-Ab-2; GM-Tg-bovg-T84614-Ab-1/ GM-Tg-bovg-T84614-Ab-2; GM-Tg-equg-T84614-Ab-1/ GM-Tg-equg-T84614-Ab-2 |
| Products Name | Anti-IL31R/IL31RA monoclonal antibody |
| Format | mab |
| Target Name | IL31R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL31R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-372 | Pre-Made Nemolizumab biosimilar, Whole mAb, Anti-IL31RA/IL31R Antibody: Anti-CRL/CRL3/GLM-R/GLMR/GPL/IL-31RA/PLCA2/PRO21384/hGLM-R/zcytoR17 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species IL31R/ IL31RA/ CRL VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T84614-Ag-1 | interleukin 31 receptor A (IL31RA) protein |
Target information
| Target ID | GM-T84614 |
| Target Name | IL31R |
| Gene ID | 133396,218624,688622,709719,487212,101095878,522636,100062017 |
| Gene Symbol and Synonyms | CRL,CRL3,GLM-R,GLMR,GPL,hGLM-R,IL-31RA,IL31RA,NR10,PLCA2,PRO21384,zcytoR17 |
| Uniprot Accession | Q8NI17 |
| Uniprot Entry Name | IL31R_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000164509 |
| Target Classification | N/A |
The target: IL31R, gene name: IL31RA, also named as CRL, CRL3, GLM-R, GLMR, GPL, IL-31RA, PLCA2, PRO21384, hGLM-R. The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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