Anti-CLCF1/ BSF-3/ BSF3 functional antibody

Anti-CLCF1/ BSF-3/ BSF3 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to CLCF1/CLCF1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T84019-Ab-1/ GM-Tg-hg-T84019-Ab-2Anti-Human CLCF1 monoclonal antibodyHuman
GM-Tg-rg-T84019-Ab-1/ GM-Tg-rg-T84019-Ab-2Anti-Rat CLCF1 monoclonal antibodyRat
GM-Tg-mg-T84019-Ab-1/ GM-Tg-mg-T84019-Ab-2Anti-Mouse CLCF1 monoclonal antibodyMouse
GM-Tg-cynog-T84019-Ab-1/ GM-Tg-cynog-T84019-Ab-2Anti-Cynomolgus/ Rhesus macaque CLCF1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T84019-Ab-1/ GM-Tg-felg-T84019-Ab-2Anti-Feline CLCF1 monoclonal antibodyFeline
GM-Tg-cang-T84019-Ab-1/ GM-Tg-cang-T84019-Ab-2Anti-Canine CLCF1 monoclonal antibodyCanine
GM-Tg-bovg-T84019-Ab-1/ GM-Tg-bovg-T84019-Ab-2Anti-Bovine CLCF1 monoclonal antibodyBovine
GM-Tg-equg-T84019-Ab-1/ GM-Tg-equg-T84019-Ab-2Anti-Equine CLCF1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T84019-Ab-1/ GM-Tg-hg-T84019-Ab-2; GM-Tg-rg-T84019-Ab-1/ GM-Tg-rg-T84019-Ab-2;
GM-Tg-mg-T84019-Ab-1/ GM-Tg-mg-T84019-Ab-2; GM-Tg-cynog-T84019-Ab-1/ GM-Tg-cynog-T84019-Ab-2;
GM-Tg-felg-T84019-Ab-1/ GM-Tg-felg-T84019-Ab-2; GM-Tg-cang-T84019-Ab-1/ GM-Tg-cang-T84019-Ab-2;
GM-Tg-bovg-T84019-Ab-1/ GM-Tg-bovg-T84019-Ab-2; GM-Tg-equg-T84019-Ab-1/ GM-Tg-equg-T84019-Ab-2
Products NameAnti-CLCF1 monoclonal antibody
Formatmab
Target NameCLCF1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CLCF1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T84019-Ag-1Recombinant multi-species CLCF1/ BSF-3/ BSF3 protein
    CytokineGM-Tg-g-T84019-Ag-1cardiotrophin-like cytokine factor 1 (CLCF1) protein
    ORF Viral VectorvGMLP003461human CLCF1 Lentivirus particle
    ORF Viral VectorpGMLP003461human CLCF1 Lentivirus plasmid
    ORF Viral VectorpGMLPm001907mouse Clcf1 Lentivirus plasmid
    ORF Viral VectorvGMLPm001907mouse Clcf1 Lentivirus particle


    Target information

    Target IDGM-T84019
    Target NameCLCF1
    Gene ID23529,56708,365395,712554,483697,101101338,100336481,100146651
    Gene Symbol and SynonymsBSF-3,BSF3,CISS2,CLC,CLCF1,NNT-1,NNT1,NR6
    Uniprot AccessionQ9UBD9
    Uniprot Entry NameCLCF1_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000175505
    Target ClassificationN/A

    The target: CLCF1, gene name: CLCF1, also named as BSF-3, BSF3, CISS2, CLC, NNT-1, NNT1, NR6. This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.