Anti-TR13C/ TNFRSF13C/ BAFF-R monoclonal antibody

Anti-TR13C/ TNFRSF13C/ BAFF-R antibody for FACS & in-vivo assay

Target products collectionGo to TNFRSF13C/TNFRSF13C products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T83687-Ab-1/ GM-Tg-hg-T83687-Ab-2Anti-Human TNFRSF13C monoclonal antibodyHuman
GM-Tg-rg-T83687-Ab-1/ GM-Tg-rg-T83687-Ab-2Anti-Rat TNFRSF13C monoclonal antibodyRat
GM-Tg-mg-T83687-Ab-1/ GM-Tg-mg-T83687-Ab-2Anti-Mouse TNFRSF13C monoclonal antibodyMouse
GM-Tg-cynog-T83687-Ab-1/ GM-Tg-cynog-T83687-Ab-2Anti-Cynomolgus/ Rhesus macaque TNFRSF13C monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T83687-Ab-1/ GM-Tg-felg-T83687-Ab-2Anti-Feline TNFRSF13C monoclonal antibodyFeline
GM-Tg-cang-T83687-Ab-1/ GM-Tg-cang-T83687-Ab-2Anti-Canine TNFRSF13C monoclonal antibodyCanine
GM-Tg-bovg-T83687-Ab-1/ GM-Tg-bovg-T83687-Ab-2Anti-Bovine TNFRSF13C monoclonal antibodyBovine
GM-Tg-equg-T83687-Ab-1/ GM-Tg-equg-T83687-Ab-2Anti-Equine TNFRSF13C monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T83687-Ab-1/ GM-Tg-hg-T83687-Ab-2; GM-Tg-rg-T83687-Ab-1/ GM-Tg-rg-T83687-Ab-2;
GM-Tg-mg-T83687-Ab-1/ GM-Tg-mg-T83687-Ab-2; GM-Tg-cynog-T83687-Ab-1/ GM-Tg-cynog-T83687-Ab-2;
GM-Tg-felg-T83687-Ab-1/ GM-Tg-felg-T83687-Ab-2; GM-Tg-cang-T83687-Ab-1/ GM-Tg-cang-T83687-Ab-2;
GM-Tg-bovg-T83687-Ab-1/ GM-Tg-bovg-T83687-Ab-2; GM-Tg-equg-T83687-Ab-1/ GM-Tg-equg-T83687-Ab-2
Products NameAnti-TNFRSF13C monoclonal antibody
Formatmab
Target NameTNFRSF13C
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNFRSF13C benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-256Pre-Made Ianalumab biosimilar, Whole mAb, Anti-TNFRSF13C Antibody: Anti-BAFF-R/BAFFR/BROMIX/CD268/CVID4/prolixin therapeutic antibody
    Target AntigenProducts DevelopingMulti-species TR13C/ TNFRSF13C/ BAFF-R VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T83687-Ag-1tumor necrosis factor receptor superfamily, member 13C (TNFRSF13C) protein
    ORF Viral VectorpGMLP004528human TNFRSF13C Lentivirus plasmid
    ORF Viral VectorvGMLP004528human TNFRSF13C Lentivirus particle
    ORF Viral VectorpGMLPm000286mouse Tnfrsf13c Lentivirus plasmid
    ORF Viral VectorvGMLPm000286mouse Tnfrsf13c Lentivirus particle


    Target information

    Target IDGM-T83687
    Target NameTNFRSF13C
    Gene ID115650,72049,500910,712577,607785,101090370,618516,100070724
    Gene Symbol and Synonyms2010006P15Rik,BAFF-R,BAFFR,Bcmd,Bcmd-1,Bcmd1,BROMIX,CD268,CVID4,Lvis22,prolixin,RGD1560810,TNFRSF13C
    Uniprot AccessionQ96RJ3
    Uniprot Entry NameTR13C_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000159958
    Target ClassificationCheckpoint-Immuno Oncology

    The target: TNFRSF13C, gene name: TNFRSF13C, also named as BAFF-R, BAFFR, BROMIX, CD268, CVID4, prolixin. B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.