Anti-DRB1/ HLA-DRB1/ HLA-DR1B monoclonal antibody

Anti-DRB1/ HLA-DRB1/ HLA-DR1B antibody for FACS & in-vivo assay

Target products collectionGo to HLA-DRB1/HLA-DRB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T83611-Ab-1/ GM-Tg-hg-T83611-Ab-2Anti-Human HLA-DRB1 monoclonal antibodyHuman
GM-Tg-rg-T83611-Ab-1/ GM-Tg-rg-T83611-Ab-2Anti-Rat HLA-DRB1 monoclonal antibodyRat
GM-Tg-mg-T83611-Ab-1/ GM-Tg-mg-T83611-Ab-2Anti-Mouse HLA-DRB1 monoclonal antibodyMouse
GM-Tg-cynog-T83611-Ab-1/ GM-Tg-cynog-T83611-Ab-2Anti-Cynomolgus/ Rhesus macaque HLA-DRB1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T83611-Ab-1/ GM-Tg-felg-T83611-Ab-2Anti-Feline HLA-DRB1 monoclonal antibodyFeline
GM-Tg-cang-T83611-Ab-1/ GM-Tg-cang-T83611-Ab-2Anti-Canine HLA-DRB1 monoclonal antibodyCanine
GM-Tg-bovg-T83611-Ab-1/ GM-Tg-bovg-T83611-Ab-2Anti-Bovine HLA-DRB1 monoclonal antibodyBovine
GM-Tg-equg-T83611-Ab-1/ GM-Tg-equg-T83611-Ab-2Anti-Equine HLA-DRB1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T83611-Ab-1/ GM-Tg-hg-T83611-Ab-2; GM-Tg-rg-T83611-Ab-1/ GM-Tg-rg-T83611-Ab-2;
GM-Tg-mg-T83611-Ab-1/ GM-Tg-mg-T83611-Ab-2; GM-Tg-cynog-T83611-Ab-1/ GM-Tg-cynog-T83611-Ab-2;
GM-Tg-felg-T83611-Ab-1/ GM-Tg-felg-T83611-Ab-2; GM-Tg-cang-T83611-Ab-1/ GM-Tg-cang-T83611-Ab-2;
GM-Tg-bovg-T83611-Ab-1/ GM-Tg-bovg-T83611-Ab-2; GM-Tg-equg-T83611-Ab-1/ GM-Tg-equg-T83611-Ab-2
Products NameAnti-HLA-DRB1 monoclonal antibody
Formatmab
Target NameHLA-DRB1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HLA-DRB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-736Pre-Made Apolizumab Biosimilar, Whole Mab, Anti-HLA-DRB/HLA-DRB1 Antibody: Anti-DRB1/SS1 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species DRB1/ HLA-DRB1/ HLA-DR1B VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMAP000059Human HLA-DRB1 Adenovirus particle
    ORF Viral VectorpGMAP000274Human HLA-DRB1 Adenovirus plasmid
    ORF Viral VectorpGMAP000059Human HLA-DRB1 Adenovirus plasmid
    ORF Viral VectorvGMAP000274Human HLA-DRB1 Adenovirus particle


    Target information

    Target IDGM-T83611
    Target NameHLA-DRB1
    Gene ID3123
    Gene Symbol and SynonymsDRB1,HLA-DR1B,HLA-DRB,HLA-DRB1,SS1
    Uniprot AccessionP01911
    Uniprot Entry NameDRB1_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseCancer
    Gene EnsemblENSG00000196126
    Target ClassificationTumor-associated antigen (TAA)

    The target: HLA-DRB1, gene name: HLA-DRB1, also named as DRB1, HLA-DR1B, HLA-DRB, SS1. HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.