Anti-UFO/ AXL/ ARK monoclonal antibody

Anti-UFO/ AXL/ ARK antibody for FACS & in-vivo assay

Target products collectionGo to AXL/AXL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T82383-Ab-1/ GM-Tg-hg-T82383-Ab-2Anti-Human AXL monoclonal antibodyHuman
GM-Tg-rg-T82383-Ab-1/ GM-Tg-rg-T82383-Ab-2Anti-Rat AXL monoclonal antibodyRat
GM-Tg-mg-T82383-Ab-1/ GM-Tg-mg-T82383-Ab-2Anti-Mouse AXL monoclonal antibodyMouse
GM-Tg-cynog-T82383-Ab-1/ GM-Tg-cynog-T82383-Ab-2Anti-Cynomolgus/ Rhesus macaque AXL monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T82383-Ab-1/ GM-Tg-felg-T82383-Ab-2Anti-Feline AXL monoclonal antibodyFeline
GM-Tg-cang-T82383-Ab-1/ GM-Tg-cang-T82383-Ab-2Anti-Canine AXL monoclonal antibodyCanine
GM-Tg-bovg-T82383-Ab-1/ GM-Tg-bovg-T82383-Ab-2Anti-Bovine AXL monoclonal antibodyBovine
GM-Tg-equg-T82383-Ab-1/ GM-Tg-equg-T82383-Ab-2Anti-Equine AXL monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T82383-Ab-1/ GM-Tg-hg-T82383-Ab-2; GM-Tg-rg-T82383-Ab-1/ GM-Tg-rg-T82383-Ab-2;
GM-Tg-mg-T82383-Ab-1/ GM-Tg-mg-T82383-Ab-2; GM-Tg-cynog-T82383-Ab-1/ GM-Tg-cynog-T82383-Ab-2;
GM-Tg-felg-T82383-Ab-1/ GM-Tg-felg-T82383-Ab-2; GM-Tg-cang-T82383-Ab-1/ GM-Tg-cang-T82383-Ab-2;
GM-Tg-bovg-T82383-Ab-1/ GM-Tg-bovg-T82383-Ab-2; GM-Tg-equg-T82383-Ab-1/ GM-Tg-equg-T82383-Ab-2
Products NameAnti-AXL monoclonal antibody
Formatmab
Target NameAXL
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-AXL benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-575Pre-Made Tilvestamab biosimilar, Whole mAb, Anti-AXL Antibody: Anti-ARK/UFO/JTK11/Tyro7 therapeutic antibody
    BiosimilarGMP-Bios-ab-179Pre-Made Enapotamab biosimilar, Whole mAb ADC, Anti-AXL Antibody: Anti-ARK/UFO/JTK11/Tyro7 therapeutic antibody
    BiosimilarGMP-Bios-INN-832Pre-Made Enapotamab Vedotin Biosimilar, Whole Mab Adc, Anti-Axl Antibody: Anti-ARK/JTK11/Tyro7/UFO therapeutic antibody Drug Conjugate
    BiosimilarGMP-Bios-ab-345Pre-Made Mipasetamab biosimilar, Whole mAb, Anti-AXL Antibody: Anti-ARK/UFO/JTK11/Tyro7 therapeutic antibody
    BiosimilarGMP-Bios-INN-910Pre-Made Mipasetamab Uzoptirine Biosimilar, Whole Mab Adc, Anti-Axl Antibody: Anti-ARK/JTK11/Tyro7/UFO therapeutic antibody Drug Conjugate
    Target AntigenProducts DevelopingMulti-species UFO/ AXL/ ARK VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP001812human AXL Lentivirus particle
    ORF Viral VectorvGMAD000544human AXL Adenovirus particle
    ORF Viral VectorpGMLP001812human AXL Lentivirus plasmid
    ORF Viral VectorpGMAD000544human AXL Adenovirus plasmid


    Target information

    Target IDGM-T82383
    Target NameAXL
    Gene ID558,26362,308444,706123,484490,101086688,516598,100064907
    Gene Symbol and SynonymsARK,AXL,JTK11,Tyro7,UFO
    Uniprot AccessionP30530
    Uniprot Entry NameUFO_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseCancer
    Gene EnsemblENSG00000167601
    Target ClassificationCheckpoint-Immuno Oncology, Tumor-associated antigen (TAA)

    The target: AXL, gene name: AXL, also named as ARK, JTK11, Tyro7, UFO. The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.