Anti-KLF4 monoclonal antibody

Pre-made anti-KLF4 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to KLF4/KLF4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T81916-Ab-1/ GM-Tg-hg-T81916-Ab-2Anti-Human KLF4 monoclonal antibodyHuman
GM-Tg-rg-T81916-Ab-1/ GM-Tg-rg-T81916-Ab-2Anti-Rat KLF4 monoclonal antibodyRat
GM-Tg-mg-T81916-Ab-1/ GM-Tg-mg-T81916-Ab-2Anti-Mouse KLF4 monoclonal antibodyMouse
GM-Tg-cynog-T81916-Ab-1/ GM-Tg-cynog-T81916-Ab-2Anti-Cynomolgus/ Rhesus macaque KLF4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T81916-Ab-1/ GM-Tg-felg-T81916-Ab-2Anti-Feline KLF4 monoclonal antibodyFeline
GM-Tg-cang-T81916-Ab-1/ GM-Tg-cang-T81916-Ab-2Anti-Canine KLF4 monoclonal antibodyCanine
GM-Tg-bovg-T81916-Ab-1/ GM-Tg-bovg-T81916-Ab-2Anti-Bovine KLF4 monoclonal antibodyBovine
GM-Tg-equg-T81916-Ab-1/ GM-Tg-equg-T81916-Ab-2Anti-Equine KLF4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T81916-Ab-1/ GM-Tg-hg-T81916-Ab-2; GM-Tg-rg-T81916-Ab-1/ GM-Tg-rg-T81916-Ab-2;
GM-Tg-mg-T81916-Ab-1/ GM-Tg-mg-T81916-Ab-2; GM-Tg-cynog-T81916-Ab-1/ GM-Tg-cynog-T81916-Ab-2;
GM-Tg-felg-T81916-Ab-1/ GM-Tg-felg-T81916-Ab-2; GM-Tg-cang-T81916-Ab-1/ GM-Tg-cang-T81916-Ab-2;
GM-Tg-bovg-T81916-Ab-1/ GM-Tg-bovg-T81916-Ab-2; GM-Tg-equg-T81916-Ab-1/ GM-Tg-equg-T81916-Ab-2
Products NameAnti-KLF4 monoclonal antibody
Formatmab
Target NameKLF4
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-KLF4 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T81916-Ag-1Recombinant multi-species KLF4/ EZF/ GKLF protein
    ORF Viral VectorvGMAD000164human KLF4 Adenovirus particle
    ORF Viral VectorvGMLV000247human KLF4 Lentivirus particle
    ORF Viral VectorpGMLV000247human KLF4 Lentivirus plasmid
    ORF Viral VectorpGMAD000164human KLF4 Adenovirus plasmid
    ORF Viral VectorpGMAD000237mouse Klf4 Adenovirus plasmid
    ORF Viral VectorpGMAD000361rat Klf4 Adenovirus plasmid
    ORF Viral VectorpGMAAV000090rat Klf4 AAV plasmid
    ORF Viral VectorpGMAAV000259house mouse Klf4 AAV plasmid
    ORF Viral VectorvGMAD000237mouse Klf4 Adenovirus particle
    ORF Viral VectorvGMAD000361rat Klf4 Adenovirus particle
    ORF Viral VectorvGMAAV000090rat Klf4 AAV particle
    ORF Viral VectorvGMAAV000259house mouse Klf4 AAV particle


    Target information

    Target IDGM-T81916
    Target NameKLF4
    Gene ID9314,16600,114505,711169,481657,100379626,520842,100054047
    Gene Symbol and SynonymsEZF,GKLF,KLF4,Zie
    Uniprot AccessionO43474
    Uniprot Entry NameKLF4_HUMAN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000136826
    Target ClassificationTumor-associated antigen (TAA)

    The target: KLF4, gene name: KLF4, also named as EZF, GKLF. This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.