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Anti-VPP3/ TCIRG1/ ATP6N1C monoclonal antibody
Anti-VPP3/ TCIRG1/ ATP6N1C antibody for FACS & in-vivo assay
Go to TCIRG1/TCIRG1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T80912-Ab-1/ GM-Tg-hg-T80912-Ab-2 | Anti-Human TCIRG1 monoclonal antibody | Human |
| GM-Tg-rg-T80912-Ab-1/ GM-Tg-rg-T80912-Ab-2 | Anti-Rat TCIRG1 monoclonal antibody | Rat |
| GM-Tg-mg-T80912-Ab-1/ GM-Tg-mg-T80912-Ab-2 | Anti-Mouse TCIRG1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T80912-Ab-1/ GM-Tg-cynog-T80912-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TCIRG1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T80912-Ab-1/ GM-Tg-felg-T80912-Ab-2 | Anti-Feline TCIRG1 monoclonal antibody | Feline |
| GM-Tg-cang-T80912-Ab-1/ GM-Tg-cang-T80912-Ab-2 | Anti-Canine TCIRG1 monoclonal antibody | Canine |
| GM-Tg-bovg-T80912-Ab-1/ GM-Tg-bovg-T80912-Ab-2 | Anti-Bovine TCIRG1 monoclonal antibody | Bovine |
| GM-Tg-equg-T80912-Ab-1/ GM-Tg-equg-T80912-Ab-2 | Anti-Equine TCIRG1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T80912-Ab-1/ GM-Tg-hg-T80912-Ab-2; GM-Tg-rg-T80912-Ab-1/ GM-Tg-rg-T80912-Ab-2; GM-Tg-mg-T80912-Ab-1/ GM-Tg-mg-T80912-Ab-2; GM-Tg-cynog-T80912-Ab-1/ GM-Tg-cynog-T80912-Ab-2; GM-Tg-felg-T80912-Ab-1/ GM-Tg-felg-T80912-Ab-2; GM-Tg-cang-T80912-Ab-1/ GM-Tg-cang-T80912-Ab-2; GM-Tg-bovg-T80912-Ab-1/ GM-Tg-bovg-T80912-Ab-2; GM-Tg-equg-T80912-Ab-1/ GM-Tg-equg-T80912-Ab-2 |
| Products Name | Anti-TCIRG1 monoclonal antibody |
| Format | mab |
| Target Name | TCIRG1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TCIRG1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species VPP3/ TCIRG1/ ATP6N1C VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP004190 | human TCIRG1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004190 | human TCIRG1 Lentivirus particle |
Target information
| Target ID | GM-T80912 |
| Target Name | TCIRG1 |
| Gene ID | 10312,27060,293650,710650,483691,101083709,513684,100146660 |
| Gene Symbol and Synonyms | a3,ATP6a3,Atp6i,ATP6N1C,ATP6V0A3,oc,OC-116,OC-116kDa,OC116,OPTB1,Stv1,TCIRG1,TIRC7,Vph1 |
| Uniprot Accession | Q13488 |
| Uniprot Entry Name | VPP3_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000110719 |
| Target Classification | N/A |
The target: TCIRG1, gene name: TCIRG1, also named as ATP6N1C, ATP6V0A3, Atp6i, OC-116kDa, OC116, OPTB1, Stv1, TIRC7, Vph1, a3. This gene encodes a subunit of a large protein complex known as a vacuolar H+-ATPase (V-ATPase). The protein complex acts as a pump to move protons across the membrane. This movement of protons helps regulate the pH of cells and their surrounding environment. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Alternative splicing results in multiple transcript variants. Mutations in this gene are associated with infantile malignant osteopetrosis. [provided by RefSeq, May 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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