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Anti-OSMR/ IL-31R-beta/ IL-31RBB monoclonal antibody
Anti-OSMR/ IL-31R-beta/ IL-31RBB antibody for FACS & in-vivo assay
Go to OSMR/OSMR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T78567-Ab-1/ GM-Tg-hg-T78567-Ab-2 | Anti-Human OSMR monoclonal antibody | Human |
| GM-Tg-rg-T78567-Ab-1/ GM-Tg-rg-T78567-Ab-2 | Anti-Rat OSMR monoclonal antibody | Rat |
| GM-Tg-mg-T78567-Ab-1/ GM-Tg-mg-T78567-Ab-2 | Anti-Mouse OSMR monoclonal antibody | Mouse |
| GM-Tg-cynog-T78567-Ab-1/ GM-Tg-cynog-T78567-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OSMR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T78567-Ab-1/ GM-Tg-felg-T78567-Ab-2 | Anti-Feline OSMR monoclonal antibody | Feline |
| GM-Tg-cang-T78567-Ab-1/ GM-Tg-cang-T78567-Ab-2 | Anti-Canine OSMR monoclonal antibody | Canine |
| GM-Tg-bovg-T78567-Ab-1/ GM-Tg-bovg-T78567-Ab-2 | Anti-Bovine OSMR monoclonal antibody | Bovine |
| GM-Tg-equg-T78567-Ab-1/ GM-Tg-equg-T78567-Ab-2 | Anti-Equine OSMR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T78567-Ab-1/ GM-Tg-hg-T78567-Ab-2; GM-Tg-rg-T78567-Ab-1/ GM-Tg-rg-T78567-Ab-2; GM-Tg-mg-T78567-Ab-1/ GM-Tg-mg-T78567-Ab-2; GM-Tg-cynog-T78567-Ab-1/ GM-Tg-cynog-T78567-Ab-2; GM-Tg-felg-T78567-Ab-1/ GM-Tg-felg-T78567-Ab-2; GM-Tg-cang-T78567-Ab-1/ GM-Tg-cang-T78567-Ab-2; GM-Tg-bovg-T78567-Ab-1/ GM-Tg-bovg-T78567-Ab-2; GM-Tg-equg-T78567-Ab-1/ GM-Tg-equg-T78567-Ab-2 |
| Products Name | Anti-OSMR monoclonal antibody |
| Format | mab |
| Target Name | OSMR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-OSMR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-623 | Pre-Made Vixarelimab biosimilar, Whole mAb, Anti-OSMR Antibody: Anti-IL-31R-beta/IL-31RB/OSMRB/OSMRbeta/PLCA1 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species OSMR/ IL-31R-beta/ IL-31RBB VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T78567-Ag-1 | oncostatin M receptor (OSMR) protein |
Target information
| Target ID | GM-T78567 |
| Target Name | OSMR |
| Gene ID | 9180,18414,310132,693569,489223,101096447,514720,100066819 |
| Gene Symbol and Synonyms | IL-31R-beta,IL-31RB,OSMR,OSMRB,OSMRbeta,PLCA1 |
| Uniprot Accession | Q99650,Q65Z14 |
| Uniprot Entry Name | OSMR_HUMAN,OSMR_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000145623 |
| Target Classification | N/A |
The target: OSMR, gene name: OSMR, also named as IL-31R-beta, IL-31RBB, PLCA1, OSMR. This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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