Anti-IFNG/ IFG/ IFI functional antibody

Anti-IFNG/ IFG/ IFI functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to IFNG/IFNG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T77664-Ab-1/ GM-Tg-hg-T77664-Ab-2Anti-Human IFNG monoclonal antibodyHuman
GM-Tg-rg-T77664-Ab-1/ GM-Tg-rg-T77664-Ab-2Anti-Rat IFNG monoclonal antibodyRat
GM-Tg-mg-T77664-Ab-1/ GM-Tg-mg-T77664-Ab-2Anti-Mouse IFNG monoclonal antibodyMouse
GM-Tg-cynog-T77664-Ab-1/ GM-Tg-cynog-T77664-Ab-2Anti-Cynomolgus/ Rhesus macaque IFNG monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T77664-Ab-1/ GM-Tg-felg-T77664-Ab-2Anti-Feline IFNG monoclonal antibodyFeline
GM-Tg-cang-T77664-Ab-1/ GM-Tg-cang-T77664-Ab-2Anti-Canine IFNG monoclonal antibodyCanine
GM-Tg-bovg-T77664-Ab-1/ GM-Tg-bovg-T77664-Ab-2Anti-Bovine IFNG monoclonal antibodyBovine
GM-Tg-equg-T77664-Ab-1/ GM-Tg-equg-T77664-Ab-2Anti-Equine IFNG monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T77664-Ab-1/ GM-Tg-hg-T77664-Ab-2; GM-Tg-rg-T77664-Ab-1/ GM-Tg-rg-T77664-Ab-2;
GM-Tg-mg-T77664-Ab-1/ GM-Tg-mg-T77664-Ab-2; GM-Tg-cynog-T77664-Ab-1/ GM-Tg-cynog-T77664-Ab-2;
GM-Tg-felg-T77664-Ab-1/ GM-Tg-felg-T77664-Ab-2; GM-Tg-cang-T77664-Ab-1/ GM-Tg-cang-T77664-Ab-2;
GM-Tg-bovg-T77664-Ab-1/ GM-Tg-bovg-T77664-Ab-2; GM-Tg-equg-T77664-Ab-1/ GM-Tg-equg-T77664-Ab-2
Products NameAnti-IFNG monoclonal antibody
Formatmab
Target NameIFNG
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IFNG benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-175Pre-Made Emapalumab biosimilar, Whole mAb, Anti-IFNG Antibody: Anti-IFG/IFI/IMD69 therapeutic antibody
    BiosimilarGMP-Bios-ab-219Pre-Made Fontolizumab biosimilar, Whole mAb, Anti-IFNG Antibody: Anti-IFG/IFI/IMD69 therapeutic antibody
    Target AntigenGM-Tg-g-T77664-Ag-1Recombinant multi-species IFNG/ IFG/ IFI protein
    CytokineGM-Tg-g-T77664-Ag-1interferon, gamma (IFNG) protein
    ORF Viral VectorvGMAD000575human IFNG Adenovirus particle
    ORF Viral VectorpGMAP000297Human IFNG Adenovirus plasmid
    ORF Viral VectorvGMLP000461human IFNG Lentivirus particle
    ORF Viral VectorvGMAP000297Human IFNG Adenovirus particle
    ORF Viral VectorpGMAD000575human IFNG Adenovirus plasmid
    ORF Viral VectorpGMLP000461human IFNG Lentivirus plasmid
    ORF Viral VectorpGMLPm000110mouse Ifng Lentivirus plasmid
    ORF Viral VectorvGMLPm000110mouse Ifng Lentivirus particle


    Target information

    Target IDGM-T77664
    Target NameIFNG
    Gene ID3458,15978,25712,574282,403801,493965,281237,100034181
    Gene Symbol and SynonymsIf2f,IFG,IFI,IFN-g,IFN-gamma,IFNG,IFNG2,IMD69
    Uniprot AccessionP01579,P01581,P63310,P42161,P46402,P07353,P42160
    Uniprot Entry NameIFNG_HUMAN,IFNG_MACMU,IFNG_RAT,IFNG_FELCA,IFNG_CANLF,IFNG_BOVIN,IFNG_HORSE
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Diagnostics Biomarker, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseBreast Cancer
    Gene EnsemblENSG00000111537
    Target ClassificationCheckpoint-Immuno Oncology

    The target: IFNG, gene name: IFNG, also named as IFG, IFI. This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.