Anti-TR10A/ TRAIL-R1/ TNFRSF10A monoclonal antibody

Anti-TR10A/ TRAIL-R1/ TNFRSF10A antibody for FACS & in-vivo assay

Target products collectionGo to TRAIL-R1/TNFRSF10A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T77645-Ab-1/ GM-Tg-hg-T77645-Ab-2Anti-Human TRAIL-R1/TNFRSF10A monoclonal antibodyHuman
GM-Tg-rg-T77645-Ab-1/ GM-Tg-rg-T77645-Ab-2Anti-Rat TRAIL-R1/TNFRSF10A monoclonal antibodyRat
GM-Tg-mg-T77645-Ab-1/ GM-Tg-mg-T77645-Ab-2Anti-Mouse TRAIL-R1/TNFRSF10A monoclonal antibodyMouse
GM-Tg-cynog-T77645-Ab-1/ GM-Tg-cynog-T77645-Ab-2Anti-Cynomolgus/ Rhesus macaque TRAIL-R1/TNFRSF10A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T77645-Ab-1/ GM-Tg-felg-T77645-Ab-2Anti-Feline TRAIL-R1/TNFRSF10A monoclonal antibodyFeline
GM-Tg-cang-T77645-Ab-1/ GM-Tg-cang-T77645-Ab-2Anti-Canine TRAIL-R1/TNFRSF10A monoclonal antibodyCanine
GM-Tg-bovg-T77645-Ab-1/ GM-Tg-bovg-T77645-Ab-2Anti-Bovine TRAIL-R1/TNFRSF10A monoclonal antibodyBovine
GM-Tg-equg-T77645-Ab-1/ GM-Tg-equg-T77645-Ab-2Anti-Equine TRAIL-R1/TNFRSF10A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T77645-Ab-1/ GM-Tg-hg-T77645-Ab-2; GM-Tg-rg-T77645-Ab-1/ GM-Tg-rg-T77645-Ab-2;
GM-Tg-mg-T77645-Ab-1/ GM-Tg-mg-T77645-Ab-2; GM-Tg-cynog-T77645-Ab-1/ GM-Tg-cynog-T77645-Ab-2;
GM-Tg-felg-T77645-Ab-1/ GM-Tg-felg-T77645-Ab-2; GM-Tg-cang-T77645-Ab-1/ GM-Tg-cang-T77645-Ab-2;
GM-Tg-bovg-T77645-Ab-1/ GM-Tg-bovg-T77645-Ab-2; GM-Tg-equg-T77645-Ab-1/ GM-Tg-equg-T77645-Ab-2
Products NameAnti-TRAIL-R1/TNFRSF10A monoclonal antibody
Formatmab
Target NameTRAIL-R1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TRAIL-R1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-905Pre-Made Mapatumumab Biosimilar, Whole Mab, Anti-TNFRSF10A/TRAIL-R1 Antibody: Anti-APO2/CD261/DR4/TRAILR-1/TRAILR1 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species TR10A/ TRAIL-R1/ TNFRSF10A VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T77645-Ag-1Tumor necrosis factor receptor superfamily, member 10a (TNFRSF10A) protein
    ORF Viral VectorvGMLP003737human TNFRSF10A Lentivirus particle
    ORF Viral VectorpGMLP003737human TNFRSF10A Lentivirus plasmid


    Target information

    Target IDGM-T77645
    Target NameTRAIL-R1
    Gene ID8797,716826
    Gene Symbol and SynonymsAPO2,CD261,DR4,TNFRSF10A,TRAILR-1,TRAILR1
    Uniprot AccessionO00220
    Uniprot Entry NameTR10A_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000104689
    Target ClassificationCheckpoint-Immuno Oncology, Tumor-associated antigen (TAA)

    The target: TRAIL-R1, gene name: TNFRSF10A, also named as APO2, CD261, DR4, TRAILR-1, TRAILR1. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.