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Anti-PAH monoclonal antibody
Pre-made anti-PAH monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PAH/PAH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T76213-Ab-1/ GM-Tg-hg-T76213-Ab-2 | Anti-Human PAH monoclonal antibody | Human |
| GM-Tg-rg-T76213-Ab-1/ GM-Tg-rg-T76213-Ab-2 | Anti-Rat PAH monoclonal antibody | Rat |
| GM-Tg-mg-T76213-Ab-1/ GM-Tg-mg-T76213-Ab-2 | Anti-Mouse PAH monoclonal antibody | Mouse |
| GM-Tg-cynog-T76213-Ab-1/ GM-Tg-cynog-T76213-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PAH monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T76213-Ab-1/ GM-Tg-felg-T76213-Ab-2 | Anti-Feline PAH monoclonal antibody | Feline |
| GM-Tg-cang-T76213-Ab-1/ GM-Tg-cang-T76213-Ab-2 | Anti-Canine PAH monoclonal antibody | Canine |
| GM-Tg-bovg-T76213-Ab-1/ GM-Tg-bovg-T76213-Ab-2 | Anti-Bovine PAH monoclonal antibody | Bovine |
| GM-Tg-equg-T76213-Ab-1/ GM-Tg-equg-T76213-Ab-2 | Anti-Equine PAH monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T76213-Ab-1/ GM-Tg-hg-T76213-Ab-2; GM-Tg-rg-T76213-Ab-1/ GM-Tg-rg-T76213-Ab-2; GM-Tg-mg-T76213-Ab-1/ GM-Tg-mg-T76213-Ab-2; GM-Tg-cynog-T76213-Ab-1/ GM-Tg-cynog-T76213-Ab-2; GM-Tg-felg-T76213-Ab-1/ GM-Tg-felg-T76213-Ab-2; GM-Tg-cang-T76213-Ab-1/ GM-Tg-cang-T76213-Ab-2; GM-Tg-bovg-T76213-Ab-1/ GM-Tg-bovg-T76213-Ab-2; GM-Tg-equg-T76213-Ab-1/ GM-Tg-equg-T76213-Ab-2 |
| Products Name | Anti-PAH monoclonal antibody |
| Format | mab |
| Target Name | PAH |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PAH monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T76213-Ag-1 | Recombinant multi-species PH4H/ PAH/ PH protein |
| ORF Viral Vector | pGMLP003716 | human PAH Lentivirus plasmid |
| ORF Viral Vector | vGMLP003716 | human PAH Lentivirus particle |
| ORF Viral Vector | pGMLPm001594 | mouse Pah Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001594 | mouse Pah Lentivirus particle |
Target information
| Target ID | GM-T76213 |
| Target Name | PAH |
| Gene ID | 5053,18478,24616,698696,475446,101081741,510583,100053361 |
| Gene Symbol and Synonyms | PAH,PH,PKU,PKU1 |
| Uniprot Accession | P00439,P04176,Q2KIH7 |
| Uniprot Entry Name | PH4H_HUMAN,PH4H_RAT,PH4H_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000171759 |
| Target Classification | N/A |
The target: PAH, gene name: PAH, also named as PH, PKU, PKU1. This gene encodes a member of the biopterin-dependent aromatic amino acid hydroxylase protein family. The encoded phenylalanine hydroxylase enzyme hydroxylates phenylalanine to tyrosine and is the rate-limiting step in phenylalanine catabolism. Deficiency of this enzyme activity results in the autosomal recessive disorder phenylketonuria. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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