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Anti-YES/ YES1/ HsT441 monoclonal antibody
Anti-YES/ YES1/ HsT441 antibody for FACS & in-vivo assay
Go to YES/YES1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T75570-Ab-1/ GM-Tg-hg-T75570-Ab-2 | Anti-Human YES/YES1 monoclonal antibody | Human |
| GM-Tg-rg-T75570-Ab-1/ GM-Tg-rg-T75570-Ab-2 | Anti-Rat YES/YES1 monoclonal antibody | Rat |
| GM-Tg-mg-T75570-Ab-1/ GM-Tg-mg-T75570-Ab-2 | Anti-Mouse YES/YES1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T75570-Ab-1/ GM-Tg-cynog-T75570-Ab-2 | Anti-Cynomolgus/ Rhesus macaque YES/YES1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T75570-Ab-1/ GM-Tg-felg-T75570-Ab-2 | Anti-Feline YES/YES1 monoclonal antibody | Feline |
| GM-Tg-cang-T75570-Ab-1/ GM-Tg-cang-T75570-Ab-2 | Anti-Canine YES/YES1 monoclonal antibody | Canine |
| GM-Tg-bovg-T75570-Ab-1/ GM-Tg-bovg-T75570-Ab-2 | Anti-Bovine YES/YES1 monoclonal antibody | Bovine |
| GM-Tg-equg-T75570-Ab-1/ GM-Tg-equg-T75570-Ab-2 | Anti-Equine YES/YES1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T75570-Ab-1/ GM-Tg-hg-T75570-Ab-2; GM-Tg-rg-T75570-Ab-1/ GM-Tg-rg-T75570-Ab-2; GM-Tg-mg-T75570-Ab-1/ GM-Tg-mg-T75570-Ab-2; GM-Tg-cynog-T75570-Ab-1/ GM-Tg-cynog-T75570-Ab-2; GM-Tg-felg-T75570-Ab-1/ GM-Tg-felg-T75570-Ab-2; GM-Tg-cang-T75570-Ab-1/ GM-Tg-cang-T75570-Ab-2; GM-Tg-bovg-T75570-Ab-1/ GM-Tg-bovg-T75570-Ab-2; GM-Tg-equg-T75570-Ab-1/ GM-Tg-equg-T75570-Ab-2 |
| Products Name | Anti-YES/YES1 monoclonal antibody |
| Format | mab |
| Target Name | YES |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-YES benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species YES/ YES1/ HsT441 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP004135 | human YES1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004135 | human YES1 Lentivirus particle |
| ORF Viral Vector | pGMLPm003043 | mouse Yes1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003043 | mouse Yes1 Lentivirus particle |
Target information
| Target ID | GM-T75570 |
| Target Name | YES |
| Gene ID | 7525,22612,24884,697099,403917,101090724,507632,100061075 |
| Gene Symbol and Synonyms | c-yes,HsT441,p60c-yes,P61-YES,Yes,YES1 |
| Uniprot Accession | P07947,F1LM93,Q28923 |
| Uniprot Entry Name | YES_HUMAN,YES_RAT,YES_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000176105 |
| Target Classification | Kinase |
The target: YES, gene name: YES1, also named as HsT441, P61-YES, Yes, c-yes. This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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