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Anti-mTOR monoclonal antibody
Pre-made anti-mTOR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to mTOR/MTOR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T75243-Ab-1/ GM-Tg-hg-T75243-Ab-2 | Anti-Human mTOR/MTOR monoclonal antibody | Human |
| GM-Tg-rg-T75243-Ab-1/ GM-Tg-rg-T75243-Ab-2 | Anti-Rat mTOR/MTOR monoclonal antibody | Rat |
| GM-Tg-mg-T75243-Ab-1/ GM-Tg-mg-T75243-Ab-2 | Anti-Mouse mTOR/MTOR monoclonal antibody | Mouse |
| GM-Tg-cynog-T75243-Ab-1/ GM-Tg-cynog-T75243-Ab-2 | Anti-Cynomolgus/ Rhesus macaque mTOR/MTOR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T75243-Ab-1/ GM-Tg-felg-T75243-Ab-2 | Anti-Feline mTOR/MTOR monoclonal antibody | Feline |
| GM-Tg-cang-T75243-Ab-1/ GM-Tg-cang-T75243-Ab-2 | Anti-Canine mTOR/MTOR monoclonal antibody | Canine |
| GM-Tg-bovg-T75243-Ab-1/ GM-Tg-bovg-T75243-Ab-2 | Anti-Bovine mTOR/MTOR monoclonal antibody | Bovine |
| GM-Tg-equg-T75243-Ab-1/ GM-Tg-equg-T75243-Ab-2 | Anti-Equine mTOR/MTOR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T75243-Ab-1/ GM-Tg-hg-T75243-Ab-2; GM-Tg-rg-T75243-Ab-1/ GM-Tg-rg-T75243-Ab-2; GM-Tg-mg-T75243-Ab-1/ GM-Tg-mg-T75243-Ab-2; GM-Tg-cynog-T75243-Ab-1/ GM-Tg-cynog-T75243-Ab-2; GM-Tg-felg-T75243-Ab-1/ GM-Tg-felg-T75243-Ab-2; GM-Tg-cang-T75243-Ab-1/ GM-Tg-cang-T75243-Ab-2; GM-Tg-bovg-T75243-Ab-1/ GM-Tg-bovg-T75243-Ab-2; GM-Tg-equg-T75243-Ab-1/ GM-Tg-equg-T75243-Ab-2 |
| Products Name | Anti-mTOR/MTOR monoclonal antibody |
| Format | mab |
| Target Name | mTOR |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-mTOR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T75243-Ag-1 | Recombinant multi-species MTOR/ mTOR/ FRAP protein |
Target information
| Target ID | GM-T75243 |
| Target Name | mTOR |
| Gene ID | 2475,56717,56718,106992736,101098152,100139219,100051341 |
| Gene Symbol and Synonyms | 2610315D21Rik,flat,FRAP,FRAP1,FRAP2,MTOR,RAFT1,RAPT1,SKS |
| Uniprot Accession | P42345,P42346 |
| Uniprot Entry Name | MTOR_HUMAN,MTOR_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Non-Small Cell Lung Cancer |
| Gene Ensembl | ENSG00000198793 |
| Target Classification | Kinase |
The target: mTOR, gene name: MTOR, also named as FRAP, FRAP1, FRAP2, RAFT1, RAPT1, SKS. The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Aug 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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