Anti-ANT3/ ATIII/ SERPINC1 monoclonal antibody

Anti-ANT3/ ATIII/ SERPINC1 antibody for FACS & in-vivo assay

Target products collectionGo to ATIII/SERPINC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T73476-Ab-1/ GM-Tg-hg-T73476-Ab-2Anti-Human ATIII/SERPINC1 monoclonal antibodyHuman
GM-Tg-rg-T73476-Ab-1/ GM-Tg-rg-T73476-Ab-2Anti-Rat ATIII/SERPINC1 monoclonal antibodyRat
GM-Tg-mg-T73476-Ab-1/ GM-Tg-mg-T73476-Ab-2Anti-Mouse ATIII/SERPINC1 monoclonal antibodyMouse
GM-Tg-cynog-T73476-Ab-1/ GM-Tg-cynog-T73476-Ab-2Anti-Cynomolgus/ Rhesus macaque ATIII/SERPINC1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T73476-Ab-1/ GM-Tg-felg-T73476-Ab-2Anti-Feline ATIII/SERPINC1 monoclonal antibodyFeline
GM-Tg-cang-T73476-Ab-1/ GM-Tg-cang-T73476-Ab-2Anti-Canine ATIII/SERPINC1 monoclonal antibodyCanine
GM-Tg-bovg-T73476-Ab-1/ GM-Tg-bovg-T73476-Ab-2Anti-Bovine ATIII/SERPINC1 monoclonal antibodyBovine
GM-Tg-equg-T73476-Ab-1/ GM-Tg-equg-T73476-Ab-2Anti-Equine ATIII/SERPINC1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T73476-Ab-1/ GM-Tg-hg-T73476-Ab-2; GM-Tg-rg-T73476-Ab-1/ GM-Tg-rg-T73476-Ab-2;
GM-Tg-mg-T73476-Ab-1/ GM-Tg-mg-T73476-Ab-2; GM-Tg-cynog-T73476-Ab-1/ GM-Tg-cynog-T73476-Ab-2;
GM-Tg-felg-T73476-Ab-1/ GM-Tg-felg-T73476-Ab-2; GM-Tg-cang-T73476-Ab-1/ GM-Tg-cang-T73476-Ab-2;
GM-Tg-bovg-T73476-Ab-1/ GM-Tg-bovg-T73476-Ab-2; GM-Tg-equg-T73476-Ab-1/ GM-Tg-equg-T73476-Ab-2
Products NameAnti-ATIII/SERPINC1 monoclonal antibody
Formatmab
Target NameATIII
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ATIII benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ANT3/ ATIII/ SERPINC1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMAAV000297human SERPINC1 AAV particle
    ORF Viral VectorpGMAAV000297human SERPINC1 AAV plasmid
    ORF Viral VectorvGMAAV000149human SERPINC1 AAV particle
    ORF Viral VectorpGMLP002891human SERPINC1 Lentivirus plasmid
    ORF Viral VectorvGMLP002891human SERPINC1 Lentivirus particle
    ORF Viral VectorpGMAAV000149human SERPINC1 AAV plasmid
    ORF Viral VectorpGMAD000029rat Serpinc1 Adenovirus plasmid
    ORF Viral VectorpGMAAV000091mouse Serpinc1 AAV plasmid
    ORF Viral VectorvGMAD000029rat Serpinc1 Adenovirus particle
    ORF Viral VectorvGMAAV000091mouse Serpinc1 AAV particle


    Target information

    Target IDGM-T73476
    Target NameATIII
    Gene ID462,11905,304917,708854,480066,101093983,540261,100061173
    Gene Symbol and SynonymsAt-3,AT3,AT3D,ATIII,ATIII-R2,ATIII-T1,ATIII-T2,SERPINC1,THPH7
    Uniprot AccessionP01008,P41361
    Uniprot Entry NameANT3_HUMAN,ANT3_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000117601
    Target ClassificationN/A

    The target: ATIII, gene name: SERPINC1, also named as AT3, AT3D, ATIII, ATIII-R2, THPH7. The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Sep 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.