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Anti-EPHB6/ HEP monoclonal antibody
Anti-EPHB6/ HEP antibody for FACS & in-vivo assay
Go to EPHB6/EPHB6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T72732-Ab-1/ GM-Tg-hg-T72732-Ab-2 | Anti-Human EPHB6 monoclonal antibody | Human |
| GM-Tg-rg-T72732-Ab-1/ GM-Tg-rg-T72732-Ab-2 | Anti-Rat EPHB6 monoclonal antibody | Rat |
| GM-Tg-mg-T72732-Ab-1/ GM-Tg-mg-T72732-Ab-2 | Anti-Mouse EPHB6 monoclonal antibody | Mouse |
| GM-Tg-cynog-T72732-Ab-1/ GM-Tg-cynog-T72732-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EPHB6 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T72732-Ab-1/ GM-Tg-felg-T72732-Ab-2 | Anti-Feline EPHB6 monoclonal antibody | Feline |
| GM-Tg-cang-T72732-Ab-1/ GM-Tg-cang-T72732-Ab-2 | Anti-Canine EPHB6 monoclonal antibody | Canine |
| GM-Tg-bovg-T72732-Ab-1/ GM-Tg-bovg-T72732-Ab-2 | Anti-Bovine EPHB6 monoclonal antibody | Bovine |
| GM-Tg-equg-T72732-Ab-1/ GM-Tg-equg-T72732-Ab-2 | Anti-Equine EPHB6 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T72732-Ab-1/ GM-Tg-hg-T72732-Ab-2; GM-Tg-rg-T72732-Ab-1/ GM-Tg-rg-T72732-Ab-2; GM-Tg-mg-T72732-Ab-1/ GM-Tg-mg-T72732-Ab-2; GM-Tg-cynog-T72732-Ab-1/ GM-Tg-cynog-T72732-Ab-2; GM-Tg-felg-T72732-Ab-1/ GM-Tg-felg-T72732-Ab-2; GM-Tg-cang-T72732-Ab-1/ GM-Tg-cang-T72732-Ab-2; GM-Tg-bovg-T72732-Ab-1/ GM-Tg-bovg-T72732-Ab-2; GM-Tg-equg-T72732-Ab-1/ GM-Tg-equg-T72732-Ab-2 |
| Products Name | Anti-EPHB6 monoclonal antibody |
| Format | mab |
| Target Name | EPHB6 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EPHB6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species EPHB6/ HEP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000240 | human EvGM6 Lentivirus particle |
| ORF Viral Vector | pGMLV000240 | human EpGM6 Lentivirus plasmid |
Target information
| Target ID | GM-T72732 |
| Target Name | EPHB6 |
| Gene ID | 2051,13848,312275,704886,119874627,101085965,529800,100055465 |
| Gene Symbol and Synonyms | Cekl,EPHB6,HEP,Mep |
| Uniprot Accession | O15197,P0C0K7 |
| Uniprot Entry Name | EPHB6_HUMAN,EPHB6_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000106123 |
| Target Classification | Kinase |
The target: EPHB6, gene name: EPHB6, also named as HEP. This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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