Anti-TNIK monoclonal antibody

Pre-made anti-TNIK monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to TNIK/TNIK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T72534-Ab-1/ GM-Tg-hg-T72534-Ab-2Anti-Human TNIK monoclonal antibodyHuman
GM-Tg-rg-T72534-Ab-1/ GM-Tg-rg-T72534-Ab-2Anti-Rat TNIK monoclonal antibodyRat
GM-Tg-mg-T72534-Ab-1/ GM-Tg-mg-T72534-Ab-2Anti-Mouse TNIK monoclonal antibodyMouse
GM-Tg-cynog-T72534-Ab-1/ GM-Tg-cynog-T72534-Ab-2Anti-Cynomolgus/ Rhesus macaque TNIK monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T72534-Ab-1/ GM-Tg-felg-T72534-Ab-2Anti-Feline TNIK monoclonal antibodyFeline
GM-Tg-cang-T72534-Ab-1/ GM-Tg-cang-T72534-Ab-2Anti-Canine TNIK monoclonal antibodyCanine
GM-Tg-bovg-T72534-Ab-1/ GM-Tg-bovg-T72534-Ab-2Anti-Bovine TNIK monoclonal antibodyBovine
GM-Tg-equg-T72534-Ab-1/ GM-Tg-equg-T72534-Ab-2Anti-Equine TNIK monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T72534-Ab-1/ GM-Tg-hg-T72534-Ab-2; GM-Tg-rg-T72534-Ab-1/ GM-Tg-rg-T72534-Ab-2;
GM-Tg-mg-T72534-Ab-1/ GM-Tg-mg-T72534-Ab-2; GM-Tg-cynog-T72534-Ab-1/ GM-Tg-cynog-T72534-Ab-2;
GM-Tg-felg-T72534-Ab-1/ GM-Tg-felg-T72534-Ab-2; GM-Tg-cang-T72534-Ab-1/ GM-Tg-cang-T72534-Ab-2;
GM-Tg-bovg-T72534-Ab-1/ GM-Tg-bovg-T72534-Ab-2; GM-Tg-equg-T72534-Ab-1/ GM-Tg-equg-T72534-Ab-2
Products NameAnti-TNIK monoclonal antibody
Formatmab
Target NameTNIK
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-TNIK monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T72534-Ag-1Recombinant multi-species TNIK/ MRT54 protein


    Target information

    Target IDGM-T72534
    Target NameTNIK
    Gene ID23043,665113,294917,695414,488166,101084310,539627,100057722
    Gene Symbol and Synonyms1500031A17Rik,4831440I19Rik,C530008O15Rik,C630040K21Rik,MRT54,RGD1561817,TNIK
    Uniprot AccessionQ9UKE5
    Uniprot Entry NameTNIK_HUMAN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000154310
    Target ClassificationKinase

    The target: TNIK, gene name: TNIK, also named as MRT54. Wnt signaling plays important roles in carcinogenesis and embryonic development. The protein encoded by this gene is a serine/threonine kinase that functions as an activator of the Wnt signaling pathway. Mutations in this gene are associated with an autosomal recessive form of cognitive disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.