Anti-MC4R monoclonal antibody

Anti-MC4R antibody for FACS & in-vivo assay

Target products collectionGo to MC4R/MC4R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T72458-Ab-1/ GM-Tg-hg-T72458-Ab-2Anti-Human MC4R monoclonal antibodyHuman
GM-Tg-rg-T72458-Ab-1/ GM-Tg-rg-T72458-Ab-2Anti-Rat MC4R monoclonal antibodyRat
GM-Tg-mg-T72458-Ab-1/ GM-Tg-mg-T72458-Ab-2Anti-Mouse MC4R monoclonal antibodyMouse
GM-Tg-cynog-T72458-Ab-1/ GM-Tg-cynog-T72458-Ab-2Anti-Cynomolgus/ Rhesus macaque MC4R monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T72458-Ab-1/ GM-Tg-felg-T72458-Ab-2Anti-Feline MC4R monoclonal antibodyFeline
GM-Tg-cang-T72458-Ab-1/ GM-Tg-cang-T72458-Ab-2Anti-Canine MC4R monoclonal antibodyCanine
GM-Tg-bovg-T72458-Ab-1/ GM-Tg-bovg-T72458-Ab-2Anti-Bovine MC4R monoclonal antibodyBovine
GM-Tg-equg-T72458-Ab-1/ GM-Tg-equg-T72458-Ab-2Anti-Equine MC4R monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T72458-Ab-1/ GM-Tg-hg-T72458-Ab-2; GM-Tg-rg-T72458-Ab-1/ GM-Tg-rg-T72458-Ab-2;
GM-Tg-mg-T72458-Ab-1/ GM-Tg-mg-T72458-Ab-2; GM-Tg-cynog-T72458-Ab-1/ GM-Tg-cynog-T72458-Ab-2;
GM-Tg-felg-T72458-Ab-1/ GM-Tg-felg-T72458-Ab-2; GM-Tg-cang-T72458-Ab-1/ GM-Tg-cang-T72458-Ab-2;
GM-Tg-bovg-T72458-Ab-1/ GM-Tg-bovg-T72458-Ab-2; GM-Tg-equg-T72458-Ab-1/ GM-Tg-equg-T72458-Ab-2
Products NameAnti-MC4R monoclonal antibody
Formatmab
Target NameMC4R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MC4R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MC4R VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000201human MC4R Lentivirus particle
    ORF Viral VectorpGMLV000201human MC4R Lentivirus plasmid
    ORF Viral VectorpGMLPm000414mouse Mc4r Lentivirus plasmid
    ORF Viral VectorvGMLPm000414mouse Mc4r Lentivirus particle


    Target information

    Target IDGM-T72458
    Target NameMC4R
    Gene ID4160,17202,25635,698596,483961,101081334,281300,100050469
    Gene Symbol and SynonymsBMIQ20,Mc4-r,MC4R,Pkcp
    Uniprot AccessionP32245,P70596,Q9GLJ8
    Uniprot Entry NameMC4R_HUMAN,MC4R_RAT,MC4R_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000166603
    Target ClassificationGPCR

    The target: MC4R, gene name: MC4R, also named as . The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.