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Anti-MR monoclonal antibody
Pre-made anti-MR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MR/NR3C2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T72168-Ab-1/ GM-Tg-hg-T72168-Ab-2 | Anti-Human MR/NR3C2 monoclonal antibody | Human |
| GM-Tg-rg-T72168-Ab-1/ GM-Tg-rg-T72168-Ab-2 | Anti-Rat MR/NR3C2 monoclonal antibody | Rat |
| GM-Tg-mg-T72168-Ab-1/ GM-Tg-mg-T72168-Ab-2 | Anti-Mouse MR/NR3C2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T72168-Ab-1/ GM-Tg-cynog-T72168-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MR/NR3C2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T72168-Ab-1/ GM-Tg-felg-T72168-Ab-2 | Anti-Feline MR/NR3C2 monoclonal antibody | Feline |
| GM-Tg-cang-T72168-Ab-1/ GM-Tg-cang-T72168-Ab-2 | Anti-Canine MR/NR3C2 monoclonal antibody | Canine |
| GM-Tg-bovg-T72168-Ab-1/ GM-Tg-bovg-T72168-Ab-2 | Anti-Bovine MR/NR3C2 monoclonal antibody | Bovine |
| GM-Tg-equg-T72168-Ab-1/ GM-Tg-equg-T72168-Ab-2 | Anti-Equine MR/NR3C2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T72168-Ab-1/ GM-Tg-hg-T72168-Ab-2; GM-Tg-rg-T72168-Ab-1/ GM-Tg-rg-T72168-Ab-2; GM-Tg-mg-T72168-Ab-1/ GM-Tg-mg-T72168-Ab-2; GM-Tg-cynog-T72168-Ab-1/ GM-Tg-cynog-T72168-Ab-2; GM-Tg-felg-T72168-Ab-1/ GM-Tg-felg-T72168-Ab-2; GM-Tg-cang-T72168-Ab-1/ GM-Tg-cang-T72168-Ab-2; GM-Tg-bovg-T72168-Ab-1/ GM-Tg-bovg-T72168-Ab-2; GM-Tg-equg-T72168-Ab-1/ GM-Tg-equg-T72168-Ab-2 |
| Products Name | Anti-MR/NR3C2 monoclonal antibody |
| Format | mab |
| Target Name | MR |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T72168-Ag-1 | Recombinant multi-species MCR/ MR/ NR3C2 protein |
| ORF Viral Vector | pGMLPm004119 | mouse Nr3c2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004119 | mouse Nr3c2 Lentivirus particle |
Target information
| Target ID | GM-T72168 |
| Target Name | MR |
| Gene ID | 4306,110784,25672,704789,475461,101081977,537614,100062570 |
| Gene Symbol and Synonyms | MCR,MLR,MR,NR3C2,NR3C2VIT |
| Uniprot Accession | P08235,P22199 |
| Uniprot Entry Name | MCR_HUMAN,MCR_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000151623 |
| Target Classification | Nuclear Receptors, Tumor-associated antigen (TAA) |
The target: MR, gene name: NR3C2, also named as MCR, MLR, MRVIT, NR3C2. This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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