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Anti-ACHA4/ CHRNA4/ BFNC monoclonal antibody
Anti-ACHA4/ CHRNA4/ BFNC antibody for FACS & in-vivo assay
Go to CHRNA4/CHRNA4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T70967-Ab-1/ GM-Tg-hg-T70967-Ab-2 | Anti-Human CHRNA4 monoclonal antibody | Human |
| GM-Tg-rg-T70967-Ab-1/ GM-Tg-rg-T70967-Ab-2 | Anti-Rat CHRNA4 monoclonal antibody | Rat |
| GM-Tg-mg-T70967-Ab-1/ GM-Tg-mg-T70967-Ab-2 | Anti-Mouse CHRNA4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T70967-Ab-1/ GM-Tg-cynog-T70967-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHRNA4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T70967-Ab-1/ GM-Tg-felg-T70967-Ab-2 | Anti-Feline CHRNA4 monoclonal antibody | Feline |
| GM-Tg-cang-T70967-Ab-1/ GM-Tg-cang-T70967-Ab-2 | Anti-Canine CHRNA4 monoclonal antibody | Canine |
| GM-Tg-bovg-T70967-Ab-1/ GM-Tg-bovg-T70967-Ab-2 | Anti-Bovine CHRNA4 monoclonal antibody | Bovine |
| GM-Tg-equg-T70967-Ab-1/ GM-Tg-equg-T70967-Ab-2 | Anti-Equine CHRNA4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T70967-Ab-1/ GM-Tg-hg-T70967-Ab-2; GM-Tg-rg-T70967-Ab-1/ GM-Tg-rg-T70967-Ab-2; GM-Tg-mg-T70967-Ab-1/ GM-Tg-mg-T70967-Ab-2; GM-Tg-cynog-T70967-Ab-1/ GM-Tg-cynog-T70967-Ab-2; GM-Tg-felg-T70967-Ab-1/ GM-Tg-felg-T70967-Ab-2; GM-Tg-cang-T70967-Ab-1/ GM-Tg-cang-T70967-Ab-2; GM-Tg-bovg-T70967-Ab-1/ GM-Tg-bovg-T70967-Ab-2; GM-Tg-equg-T70967-Ab-1/ GM-Tg-equg-T70967-Ab-2 |
| Products Name | Anti-CHRNA4 monoclonal antibody |
| Format | mab |
| Target Name | CHRNA4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CHRNA4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ACHA4/ CHRNA4/ BFNC VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002918 | human CHRNA4 Lentivirus particle |
| ORF Viral Vector | pGMLP002918 | human CHRNA4 Lentivirus plasmid |
Target information
| Target ID | GM-T70967 |
| Target Name | CHRNA4 |
| Gene ID | 1137,11438,25590,114670571,485972,101101300,537251,100146784 |
| Gene Symbol and Synonyms | Acra-4,Acra4,BFNC,CHRNA4,EBN,EBN1,ENFL1,NACHR,NACHRA4,NACRA4,NARAC |
| Uniprot Accession | P43681,P09483 |
| Uniprot Entry Name | ACHA4_HUMAN,ACHA4_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000101204 |
| Target Classification | Ion Channel |
The target: CHRNA4, gene name: CHRNA4, also named as BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4. This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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