Anti-RTN4/ ASY/ NI220/250 monoclonal antibody

Anti-RTN4/ ASY/ NI220/250 antibody for FACS & in-vivo assay

Target products collectionGo to RTN4/RTN4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T70062-Ab-1/ GM-Tg-hg-T70062-Ab-2Anti-Human RTN4 monoclonal antibodyHuman
GM-Tg-rg-T70062-Ab-1/ GM-Tg-rg-T70062-Ab-2Anti-Rat RTN4 monoclonal antibodyRat
GM-Tg-mg-T70062-Ab-1/ GM-Tg-mg-T70062-Ab-2Anti-Mouse RTN4 monoclonal antibodyMouse
GM-Tg-cynog-T70062-Ab-1/ GM-Tg-cynog-T70062-Ab-2Anti-Cynomolgus/ Rhesus macaque RTN4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T70062-Ab-1/ GM-Tg-felg-T70062-Ab-2Anti-Feline RTN4 monoclonal antibodyFeline
GM-Tg-cang-T70062-Ab-1/ GM-Tg-cang-T70062-Ab-2Anti-Canine RTN4 monoclonal antibodyCanine
GM-Tg-bovg-T70062-Ab-1/ GM-Tg-bovg-T70062-Ab-2Anti-Bovine RTN4 monoclonal antibodyBovine
GM-Tg-equg-T70062-Ab-1/ GM-Tg-equg-T70062-Ab-2Anti-Equine RTN4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T70062-Ab-1/ GM-Tg-hg-T70062-Ab-2; GM-Tg-rg-T70062-Ab-1/ GM-Tg-rg-T70062-Ab-2;
GM-Tg-mg-T70062-Ab-1/ GM-Tg-mg-T70062-Ab-2; GM-Tg-cynog-T70062-Ab-1/ GM-Tg-cynog-T70062-Ab-2;
GM-Tg-felg-T70062-Ab-1/ GM-Tg-felg-T70062-Ab-2; GM-Tg-cang-T70062-Ab-1/ GM-Tg-cang-T70062-Ab-2;
GM-Tg-bovg-T70062-Ab-1/ GM-Tg-bovg-T70062-Ab-2; GM-Tg-equg-T70062-Ab-1/ GM-Tg-equg-T70062-Ab-2
Products NameAnti-RTN4 monoclonal antibody
Formatmab
Target NameRTN4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RTN4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-037Pre-Made Atinumab biosimilar, Whole mAb, Anti-RTN4 Antibody: Anti-ASY/NI220/250/NOGO/NSP/NSP-CL/Nbla00271/Nbla10545/RTN-X-B1-B2 therapeutic antibody
    BiosimilarGMP-Bios-ab-418Pre-Made Ozanezumab biosimilar, Whole mAb, Anti-RTN4 Antibody: Anti-ASY/NI220/250/NOGO/NSP/NSP-CL/Nbla00271/Nbla10545/RTN-X-B1-B2 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species RTN4/ ASY/ NI220/250 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP002802human RTN4 Lentivirus plasmid
    ORF Viral VectorvGMLP002802human RTN4 Lentivirus particle
    ORF Viral VectorpGMLV000586Norway rat Rtn4 Lentivirus plasmid
    ORF Viral VectorpGMAAV000341house mouse Rtn4 AAV plasmid
    ORF Viral VectorvGMLV000586Norway rat Rtn4 Lentivirus particle
    ORF Viral VectorvGMAAV000341house mouse Rtn4 AAV particle


    Target information

    Target IDGM-T70062
    Target NameRTN4
    Gene ID57142,68585,83765,619181,474598,101091611,359718,100066612
    Gene Symbol and Synonyms1110020G17Rik,ASY,C130026I10Rik,mKIAA0886,mKIAA4153,Nbla00271,Nbla10545,NgA,NI-250,NI220/250,NOGO,Nogo-A,Nogo-B,Nogo-C,NSP,NSP-CL,rat N,rat NogoA,RTN-X,RTN4,RTN4-A,RTN4-B1,RTN4-B2,RTN4-C,RTN4-Cw,Vp20
    Uniprot AccessionQ9NQC3,Q9JK11
    Uniprot Entry NameRTN4_HUMAN,RTN4_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000115310
    Target ClassificationN/A

    The target: RTN4, gene name: RTN4, also named as ASY, NI220/250, NOGO, NSP, NSP-CL, Nbla00271, Nbla10545, RTN-X-A, RTN4-B1, RTN4-B2, RTN4-C, RTN4. This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.