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Anti-TP53 Y220C monoclonal antibody
Pre-made anti-TP53 Y220C monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TP53 Y220C/TP53 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T69823-Ab-1/ GM-Tg-hg-T69823-Ab-2 | Anti-Human TP53 Y220C/TP53 monoclonal antibody | Human |
| GM-Tg-rg-T69823-Ab-1/ GM-Tg-rg-T69823-Ab-2 | Anti-Rat TP53 Y220C/TP53 monoclonal antibody | Rat |
| GM-Tg-mg-T69823-Ab-1/ GM-Tg-mg-T69823-Ab-2 | Anti-Mouse TP53 Y220C/TP53 monoclonal antibody | Mouse |
| GM-Tg-cynog-T69823-Ab-1/ GM-Tg-cynog-T69823-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TP53 Y220C/TP53 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T69823-Ab-1/ GM-Tg-felg-T69823-Ab-2 | Anti-Feline TP53 Y220C/TP53 monoclonal antibody | Feline |
| GM-Tg-cang-T69823-Ab-1/ GM-Tg-cang-T69823-Ab-2 | Anti-Canine TP53 Y220C/TP53 monoclonal antibody | Canine |
| GM-Tg-bovg-T69823-Ab-1/ GM-Tg-bovg-T69823-Ab-2 | Anti-Bovine TP53 Y220C/TP53 monoclonal antibody | Bovine |
| GM-Tg-equg-T69823-Ab-1/ GM-Tg-equg-T69823-Ab-2 | Anti-Equine TP53 Y220C/TP53 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T69823-Ab-1/ GM-Tg-hg-T69823-Ab-2; GM-Tg-rg-T69823-Ab-1/ GM-Tg-rg-T69823-Ab-2; GM-Tg-mg-T69823-Ab-1/ GM-Tg-mg-T69823-Ab-2; GM-Tg-cynog-T69823-Ab-1/ GM-Tg-cynog-T69823-Ab-2; GM-Tg-felg-T69823-Ab-1/ GM-Tg-felg-T69823-Ab-2; GM-Tg-cang-T69823-Ab-1/ GM-Tg-cang-T69823-Ab-2; GM-Tg-bovg-T69823-Ab-1/ GM-Tg-bovg-T69823-Ab-2; GM-Tg-equg-T69823-Ab-1/ GM-Tg-equg-T69823-Ab-2 |
| Products Name | Anti-TP53 Y220C/TP53 monoclonal antibody |
| Format | mab |
| Target Name | TP53 Y220C |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TP53 Y220C monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T69823-Ag-1 | Recombinant multi-species P53/ TP53 Y220C/ TP53 protein |
| ORF Viral Vector | vGMAAV000014 | human TP53 AAV particle |
| ORF Viral Vector | pGMAP000334 | Human TP53 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000013 | human TP53 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000013 | human TP53 Adenovirus particle |
| ORF Viral Vector | pGMAAV000014 | human TP53 AAV plasmid |
| ORF Viral Vector | vGMAP000334 | Human TP53 Adenovirus particle |
| ORF Viral Vector | pGMAD000347 | rat Tp53 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000347 | rat Tp53 Adenovirus particle |
| ORF Viral Vector | pGMAD000539 | house mouse Trp53 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000539 | house mouse Trp53 Adenovirus particle |
Target information
| Target ID | GM-T69823 |
| Target Name | TP53 Y220C |
| Gene ID | 7157,22059,24842,716170,403869,493847,281542,100062044 |
| Gene Symbol and Synonyms | bbl,BCC7,bfy,bhy,BMFS5,LFS1,p44,P53,TP53,TRP53 |
| Uniprot Accession | P04637,P10361,P56424,Q29537,P41685,P67939,P79892 |
| Uniprot Entry Name | P53_HUMAN,P53_MACMU,P53_RAT,P53_FELCA,P53_CANLF,P53_BOVIN,P53_HORSE |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Lung Cancer, lung cancers, Lung cancer, Lung, Colon cancer, Bone metastasis, Liver neoplasms, Lung neoplasms |
| Gene Ensembl | ENSG00000141510 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: TP53 Y220C, gene name: TP53, also named as BCC7, LFS1, P53, TRP53. This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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