Anti-FGF8/ AIGF/ FGF-8 functional antibody

Anti-FGF8/ AIGF/ FGF-8 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to FGF8/FGF8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T69580-Ab-1/ GM-Tg-hg-T69580-Ab-2Anti-Human FGF8 monoclonal antibodyHuman
GM-Tg-rg-T69580-Ab-1/ GM-Tg-rg-T69580-Ab-2Anti-Rat FGF8 monoclonal antibodyRat
GM-Tg-mg-T69580-Ab-1/ GM-Tg-mg-T69580-Ab-2Anti-Mouse FGF8 monoclonal antibodyMouse
GM-Tg-cynog-T69580-Ab-1/ GM-Tg-cynog-T69580-Ab-2Anti-Cynomolgus/ Rhesus macaque FGF8 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T69580-Ab-1/ GM-Tg-felg-T69580-Ab-2Anti-Feline FGF8 monoclonal antibodyFeline
GM-Tg-cang-T69580-Ab-1/ GM-Tg-cang-T69580-Ab-2Anti-Canine FGF8 monoclonal antibodyCanine
GM-Tg-bovg-T69580-Ab-1/ GM-Tg-bovg-T69580-Ab-2Anti-Bovine FGF8 monoclonal antibodyBovine
GM-Tg-equg-T69580-Ab-1/ GM-Tg-equg-T69580-Ab-2Anti-Equine FGF8 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T69580-Ab-1/ GM-Tg-hg-T69580-Ab-2; GM-Tg-rg-T69580-Ab-1/ GM-Tg-rg-T69580-Ab-2;
GM-Tg-mg-T69580-Ab-1/ GM-Tg-mg-T69580-Ab-2; GM-Tg-cynog-T69580-Ab-1/ GM-Tg-cynog-T69580-Ab-2;
GM-Tg-felg-T69580-Ab-1/ GM-Tg-felg-T69580-Ab-2; GM-Tg-cang-T69580-Ab-1/ GM-Tg-cang-T69580-Ab-2;
GM-Tg-bovg-T69580-Ab-1/ GM-Tg-bovg-T69580-Ab-2; GM-Tg-equg-T69580-Ab-1/ GM-Tg-equg-T69580-Ab-2
Products NameAnti-FGF8 monoclonal antibody
Formatmab
Target NameFGF8
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FGF8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T69580-Ag-1Recombinant multi-species FGF8/ AIGF/ FGF-8 protein
    CytokineGM-Tg-g-T69580-Ag-1fibroblast growth factor 8 (FGF8) protein
    ORF Viral VectorpGMLP004784human FGF8 Lentivirus plasmid
    ORF Viral VectorvGMLP004784human FGF8 Lentivirus particle
    ORF Viral VectorpGMLPm004566mouse Fgf8 Lentivirus plasmid
    ORF Viral VectorvGMLPm004566mouse Fgf8 Lentivirus particle


    Target information

    Target IDGM-T69580
    Target NameFGF8
    Gene ID2253,14179,29349,722394,403868,101084652,326284,100060309
    Gene Symbol and SynonymsAIGF,FGF-8,Fgf6c,FGF8,HBGF-8,HH6,KAL6
    Uniprot AccessionP55075,O62682
    Uniprot Entry NameFGF8_HUMAN,FGF8_CANLF
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000107831
    Target ClassificationTumor-associated antigen (TAA)

    The target: FGF8, gene name: FGF8, also named as AIGF, FGF-8, HBGF-8, HH6, KAL6. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.