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Anti-CADH5/ CDH5/ 7B4 monoclonal antibody
Anti-CADH5/ CDH5/ 7B4 antibody for FACS & in-vivo assay
Go to CDH5/CDH5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T68009-Ab-1/ GM-Tg-hg-T68009-Ab-2 | Anti-Human CDH5 monoclonal antibody | Human |
| GM-Tg-rg-T68009-Ab-1/ GM-Tg-rg-T68009-Ab-2 | Anti-Rat CDH5 monoclonal antibody | Rat |
| GM-Tg-mg-T68009-Ab-1/ GM-Tg-mg-T68009-Ab-2 | Anti-Mouse CDH5 monoclonal antibody | Mouse |
| GM-Tg-cynog-T68009-Ab-1/ GM-Tg-cynog-T68009-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CDH5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T68009-Ab-1/ GM-Tg-felg-T68009-Ab-2 | Anti-Feline CDH5 monoclonal antibody | Feline |
| GM-Tg-cang-T68009-Ab-1/ GM-Tg-cang-T68009-Ab-2 | Anti-Canine CDH5 monoclonal antibody | Canine |
| GM-Tg-bovg-T68009-Ab-1/ GM-Tg-bovg-T68009-Ab-2 | Anti-Bovine CDH5 monoclonal antibody | Bovine |
| GM-Tg-equg-T68009-Ab-1/ GM-Tg-equg-T68009-Ab-2 | Anti-Equine CDH5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T68009-Ab-1/ GM-Tg-hg-T68009-Ab-2; GM-Tg-rg-T68009-Ab-1/ GM-Tg-rg-T68009-Ab-2; GM-Tg-mg-T68009-Ab-1/ GM-Tg-mg-T68009-Ab-2; GM-Tg-cynog-T68009-Ab-1/ GM-Tg-cynog-T68009-Ab-2; GM-Tg-felg-T68009-Ab-1/ GM-Tg-felg-T68009-Ab-2; GM-Tg-cang-T68009-Ab-1/ GM-Tg-cang-T68009-Ab-2; GM-Tg-bovg-T68009-Ab-1/ GM-Tg-bovg-T68009-Ab-2; GM-Tg-equg-T68009-Ab-1/ GM-Tg-equg-T68009-Ab-2 |
| Products Name | Anti-CDH5 monoclonal antibody |
| Format | mab |
| Target Name | CDH5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CDH5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CADH5/ CDH5/ 7B4 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAD000652 | human CDH5 Adenovirus particle |
| ORF Viral Vector | pGMAD000652 | human CDH5 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm004034 | mouse Cdh5 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004034 | mouse Cdh5 Lentivirus particle |
Target information
| Target ID | GM-T68009 |
| Target Name | CDH5 |
| Gene ID | 1003,12562,307618,693297,489775,101084501,414735,100065253 |
| Gene Symbol and Synonyms | 7B4,CD144,CDH5,VE-Cad,Vec,VEcad,VECD |
| Uniprot Accession | P33151,Q6URK6 |
| Uniprot Entry Name | CADH5_HUMAN,CADH5_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Chronic Kidney Disease |
| Gene Ensembl | ENSG00000179776 |
| Target Classification | N/A |
The target: CDH5, gene name: CDH5, also named as 7B4, CD144. This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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