Anti-ACM3/ CHRM3/ EGBRS monoclonal antibody

Anti-ACM3/ CHRM3/ EGBRS antibody for FACS & in-vivo assay

Target products collectionGo to CHRM3/CHRM3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T67684-Ab-1/ GM-Tg-hg-T67684-Ab-2Anti-Human CHRM3 monoclonal antibodyHuman
GM-Tg-rg-T67684-Ab-1/ GM-Tg-rg-T67684-Ab-2Anti-Rat CHRM3 monoclonal antibodyRat
GM-Tg-mg-T67684-Ab-1/ GM-Tg-mg-T67684-Ab-2Anti-Mouse CHRM3 monoclonal antibodyMouse
GM-Tg-cynog-T67684-Ab-1/ GM-Tg-cynog-T67684-Ab-2Anti-Cynomolgus/ Rhesus macaque CHRM3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T67684-Ab-1/ GM-Tg-felg-T67684-Ab-2Anti-Feline CHRM3 monoclonal antibodyFeline
GM-Tg-cang-T67684-Ab-1/ GM-Tg-cang-T67684-Ab-2Anti-Canine CHRM3 monoclonal antibodyCanine
GM-Tg-bovg-T67684-Ab-1/ GM-Tg-bovg-T67684-Ab-2Anti-Bovine CHRM3 monoclonal antibodyBovine
GM-Tg-equg-T67684-Ab-1/ GM-Tg-equg-T67684-Ab-2Anti-Equine CHRM3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T67684-Ab-1/ GM-Tg-hg-T67684-Ab-2; GM-Tg-rg-T67684-Ab-1/ GM-Tg-rg-T67684-Ab-2;
GM-Tg-mg-T67684-Ab-1/ GM-Tg-mg-T67684-Ab-2; GM-Tg-cynog-T67684-Ab-1/ GM-Tg-cynog-T67684-Ab-2;
GM-Tg-felg-T67684-Ab-1/ GM-Tg-felg-T67684-Ab-2; GM-Tg-cang-T67684-Ab-1/ GM-Tg-cang-T67684-Ab-2;
GM-Tg-bovg-T67684-Ab-1/ GM-Tg-bovg-T67684-Ab-2; GM-Tg-equg-T67684-Ab-1/ GM-Tg-equg-T67684-Ab-2
Products NameAnti-CHRM3 monoclonal antibody
Formatmab
Target NameCHRM3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CHRM3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ACM3/ CHRM3/ EGBRS VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP002057human CHRM3 Lentivirus plasmid
    ORF Viral VectorvGMLP002057human CHRM3 Lentivirus particle
    ORF Viral VectorpGMLPm003048mouse Chrm3 Lentivirus plasmid
    ORF Viral VectorpGMLPm003434mouse Chrm3 Lentivirus plasmid
    ORF Viral VectorvGMLPm003048mouse Chrm3 Lentivirus particle
    ORF Viral VectorvGMLPm003434mouse Chrm3 Lentivirus particle


    Target information

    Target IDGM-T67684
    Target NameCHRM3
    Gene ID1131,12671,24260,708901,403827,101100919,281685,100056633
    Gene Symbol and SynonymsChrm-3,CHRM3,EGBRS,HM3,M3,M3R,PBS
    Uniprot AccessionP20309,P08483,P41984
    Uniprot Entry NameACM3_HUMAN,ACM3_RAT,ACM3_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000133019
    Target ClassificationN/A

    The target: CHRM3, gene name: CHRM3, also named as EGBRS, HM3, PBS. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.