Anti-SMO/ CRJS/ FZD11 monoclonal antibody

Anti-SMO/ CRJS/ FZD11 antibody for FACS & in-vivo assay

Target products collectionGo to SMO/SMO products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T66505-Ab-1/ GM-Tg-hg-T66505-Ab-2Anti-Human SMO monoclonal antibodyHuman
GM-Tg-rg-T66505-Ab-1/ GM-Tg-rg-T66505-Ab-2Anti-Rat SMO monoclonal antibodyRat
GM-Tg-mg-T66505-Ab-1/ GM-Tg-mg-T66505-Ab-2Anti-Mouse SMO monoclonal antibodyMouse
GM-Tg-cynog-T66505-Ab-1/ GM-Tg-cynog-T66505-Ab-2Anti-Cynomolgus/ Rhesus macaque SMO monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T66505-Ab-1/ GM-Tg-felg-T66505-Ab-2Anti-Feline SMO monoclonal antibodyFeline
GM-Tg-cang-T66505-Ab-1/ GM-Tg-cang-T66505-Ab-2Anti-Canine SMO monoclonal antibodyCanine
GM-Tg-bovg-T66505-Ab-1/ GM-Tg-bovg-T66505-Ab-2Anti-Bovine SMO monoclonal antibodyBovine
GM-Tg-equg-T66505-Ab-1/ GM-Tg-equg-T66505-Ab-2Anti-Equine SMO monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T66505-Ab-1/ GM-Tg-hg-T66505-Ab-2; GM-Tg-rg-T66505-Ab-1/ GM-Tg-rg-T66505-Ab-2;
GM-Tg-mg-T66505-Ab-1/ GM-Tg-mg-T66505-Ab-2; GM-Tg-cynog-T66505-Ab-1/ GM-Tg-cynog-T66505-Ab-2;
GM-Tg-felg-T66505-Ab-1/ GM-Tg-felg-T66505-Ab-2; GM-Tg-cang-T66505-Ab-1/ GM-Tg-cang-T66505-Ab-2;
GM-Tg-bovg-T66505-Ab-1/ GM-Tg-bovg-T66505-Ab-2; GM-Tg-equg-T66505-Ab-1/ GM-Tg-equg-T66505-Ab-2
Products NameAnti-SMO monoclonal antibody
Formatmab
Target NameSMO
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-SMO benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species SMO/ CRJS/ FZD11 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T66505
    Target NameSMO
    Gene ID6608,319757,25273,701334,482262,101087567,539308,100033990
    Gene Symbol and Synonymsbnb,CRJS,E130215L21Rik,FZD11,Gx,PHLS,SMO,SMOH,smoothened
    Uniprot AccessionQ99835,P97698
    Uniprot Entry NameSMO_HUMAN,SMO_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseNon-Small Cell Lung Cancer
    Gene EnsemblENSG00000128602
    Target ClassificationGPCR

    The target: SMO, gene name: SMO, also named as CRJS, FZD11, GxH, SMO. The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex. [provided by RefSeq, Jul 2010].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.