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Anti-CFAD/ CFD/ ADIPSIN functional antibody
Anti-CFAD/ CFD/ ADIPSIN functional antibody for cell culture, ELISA & in-vivo assay
Go to CFD/CFD products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T66383-Ab-1/ GM-Tg-hg-T66383-Ab-2 | Anti-Human CFD monoclonal antibody | Human |
| GM-Tg-rg-T66383-Ab-1/ GM-Tg-rg-T66383-Ab-2 | Anti-Rat CFD monoclonal antibody | Rat |
| GM-Tg-mg-T66383-Ab-1/ GM-Tg-mg-T66383-Ab-2 | Anti-Mouse CFD monoclonal antibody | Mouse |
| GM-Tg-cynog-T66383-Ab-1/ GM-Tg-cynog-T66383-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CFD monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T66383-Ab-1/ GM-Tg-felg-T66383-Ab-2 | Anti-Feline CFD monoclonal antibody | Feline |
| GM-Tg-cang-T66383-Ab-1/ GM-Tg-cang-T66383-Ab-2 | Anti-Canine CFD monoclonal antibody | Canine |
| GM-Tg-bovg-T66383-Ab-1/ GM-Tg-bovg-T66383-Ab-2 | Anti-Bovine CFD monoclonal antibody | Bovine |
| GM-Tg-equg-T66383-Ab-1/ GM-Tg-equg-T66383-Ab-2 | Anti-Equine CFD monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T66383-Ab-1/ GM-Tg-hg-T66383-Ab-2; GM-Tg-rg-T66383-Ab-1/ GM-Tg-rg-T66383-Ab-2; GM-Tg-mg-T66383-Ab-1/ GM-Tg-mg-T66383-Ab-2; GM-Tg-cynog-T66383-Ab-1/ GM-Tg-cynog-T66383-Ab-2; GM-Tg-felg-T66383-Ab-1/ GM-Tg-felg-T66383-Ab-2; GM-Tg-cang-T66383-Ab-1/ GM-Tg-cang-T66383-Ab-2; GM-Tg-bovg-T66383-Ab-1/ GM-Tg-bovg-T66383-Ab-2; GM-Tg-equg-T66383-Ab-1/ GM-Tg-equg-T66383-Ab-2 |
| Products Name | Anti-CFD monoclonal antibody |
| Format | mab |
| Target Name | CFD |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CFD benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-293 | Pre-Made Lampalizumab biosimilar, Fab, Anti-CFD Antibody: Anti-ADIPSIN/ADN/DF/PFD therapeutic antibody |
| Target Antigen | GM-Tg-g-T66383-Ag-1 | Recombinant multi-species CFAD/ CFD/ ADIPSIN protein |
| Cytokine | GM-Tg-g-T66383-Ag-1 | complement factor D (adipsin) (CFD) protein |
| ORF Viral Vector | vGMLP004900 | human CFD Lentivirus particle |
| ORF Viral Vector | pGMLP004900 | human CFD Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003243 | mouse Cfd Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003243 | mouse Cfd Lentivirus particle |
Target information
| Target ID | GM-T66383 |
| Target Name | CFD |
| Gene ID | 1675,11537,54249,721138,485095,101093500,505647,111774154 |
| Gene Symbol and Synonyms | ADIPSIN,ADN,CFD,DF,EVE,PFD |
| Uniprot Accession | P00746,P32038,Q3T0A3 |
| Uniprot Entry Name | CFAD_HUMAN,CFAD_RAT,CFAD_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Dent disease |
| Gene Ensembl | ENSG00000197766 |
| Target Classification | N/A |
The target: CFD, gene name: CFD, also named as ADIPSIN, ADN, DF, PFD. This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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