Anti-NRG1/ Pro-NRG1/ ARIA functional antibody

Anti-NRG1/ Pro-NRG1/ ARIA functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to Pro-NRG1/NRG1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T65198-Ab-1/ GM-Tg-hg-T65198-Ab-2Anti-Human Pro-NRG1/NRG1 monoclonal antibodyHuman
GM-Tg-rg-T65198-Ab-1/ GM-Tg-rg-T65198-Ab-2Anti-Rat Pro-NRG1/NRG1 monoclonal antibodyRat
GM-Tg-mg-T65198-Ab-1/ GM-Tg-mg-T65198-Ab-2Anti-Mouse Pro-NRG1/NRG1 monoclonal antibodyMouse
GM-Tg-cynog-T65198-Ab-1/ GM-Tg-cynog-T65198-Ab-2Anti-Cynomolgus/ Rhesus macaque Pro-NRG1/NRG1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T65198-Ab-1/ GM-Tg-felg-T65198-Ab-2Anti-Feline Pro-NRG1/NRG1 monoclonal antibodyFeline
GM-Tg-cang-T65198-Ab-1/ GM-Tg-cang-T65198-Ab-2Anti-Canine Pro-NRG1/NRG1 monoclonal antibodyCanine
GM-Tg-bovg-T65198-Ab-1/ GM-Tg-bovg-T65198-Ab-2Anti-Bovine Pro-NRG1/NRG1 monoclonal antibodyBovine
GM-Tg-equg-T65198-Ab-1/ GM-Tg-equg-T65198-Ab-2Anti-Equine Pro-NRG1/NRG1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T65198-Ab-1/ GM-Tg-hg-T65198-Ab-2; GM-Tg-rg-T65198-Ab-1/ GM-Tg-rg-T65198-Ab-2;
GM-Tg-mg-T65198-Ab-1/ GM-Tg-mg-T65198-Ab-2; GM-Tg-cynog-T65198-Ab-1/ GM-Tg-cynog-T65198-Ab-2;
GM-Tg-felg-T65198-Ab-1/ GM-Tg-felg-T65198-Ab-2; GM-Tg-cang-T65198-Ab-1/ GM-Tg-cang-T65198-Ab-2;
GM-Tg-bovg-T65198-Ab-1/ GM-Tg-bovg-T65198-Ab-2; GM-Tg-equg-T65198-Ab-1/ GM-Tg-equg-T65198-Ab-2
Products NameAnti-Pro-NRG1/NRG1 monoclonal antibody
Formatmab
Target NamePro-NRG1
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-Pro-NRG1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T65198-Ag-1Recombinant multi-species NRG1/ Pro-NRG1/ ARIA protein
    CytokineGM-Tg-g-T65198-Ag-1neuregulin 1 (NRG1) protein
    ORF Viral VectorpGMLPm003571mouse Nrg1 Lentivirus plasmid
    ORF Viral VectorvGMLPm003571mouse Nrg1 Lentivirus particle


    Target information

    Target IDGM-T65198
    Target NamePro-NRG1
    Gene ID3084,211323,112400,696275,482861,101096805,281361,100061417
    Gene Symbol and Synonyms6030402G23Rik,ARIA,D230005F13Rik,GGF,GGF2,GGFII,HGL,HRG,HRG1,HRGA,HRGalpha,MST131,MSTP131,NDF,NRG1,NRG1-IT2,Pro-NRG1,SMDF
    Uniprot AccessionQ02297,P43322
    Uniprot Entry NameNRG1_HUMAN,NRG1_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000157168
    Target ClassificationTumor-associated antigen (TAA)

    The target: Pro-NRG1, gene name: NRG1, also named as ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF-IT2, SMDF, NRG1. The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.