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Anti-TNR21/ CD358/ TNFRSF21 monoclonal antibody
Anti-TNR21/ CD358/ TNFRSF21 antibody for FACS & in-vivo assay
Go to CD358/TNFRSF21 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T64744-Ab-1/ GM-Tg-hg-T64744-Ab-2 | Anti-Human CD358/TNFRSF21 monoclonal antibody | Human |
| GM-Tg-rg-T64744-Ab-1/ GM-Tg-rg-T64744-Ab-2 | Anti-Rat CD358/TNFRSF21 monoclonal antibody | Rat |
| GM-Tg-mg-T64744-Ab-1/ GM-Tg-mg-T64744-Ab-2 | Anti-Mouse CD358/TNFRSF21 monoclonal antibody | Mouse |
| GM-Tg-cynog-T64744-Ab-1/ GM-Tg-cynog-T64744-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CD358/TNFRSF21 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T64744-Ab-1/ GM-Tg-felg-T64744-Ab-2 | Anti-Feline CD358/TNFRSF21 monoclonal antibody | Feline |
| GM-Tg-cang-T64744-Ab-1/ GM-Tg-cang-T64744-Ab-2 | Anti-Canine CD358/TNFRSF21 monoclonal antibody | Canine |
| GM-Tg-bovg-T64744-Ab-1/ GM-Tg-bovg-T64744-Ab-2 | Anti-Bovine CD358/TNFRSF21 monoclonal antibody | Bovine |
| GM-Tg-equg-T64744-Ab-1/ GM-Tg-equg-T64744-Ab-2 | Anti-Equine CD358/TNFRSF21 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T64744-Ab-1/ GM-Tg-hg-T64744-Ab-2; GM-Tg-rg-T64744-Ab-1/ GM-Tg-rg-T64744-Ab-2; GM-Tg-mg-T64744-Ab-1/ GM-Tg-mg-T64744-Ab-2; GM-Tg-cynog-T64744-Ab-1/ GM-Tg-cynog-T64744-Ab-2; GM-Tg-felg-T64744-Ab-1/ GM-Tg-felg-T64744-Ab-2; GM-Tg-cang-T64744-Ab-1/ GM-Tg-cang-T64744-Ab-2; GM-Tg-bovg-T64744-Ab-1/ GM-Tg-bovg-T64744-Ab-2; GM-Tg-equg-T64744-Ab-1/ GM-Tg-equg-T64744-Ab-2 |
| Products Name | Anti-CD358/TNFRSF21 monoclonal antibody |
| Format | mab |
| Target Name | CD358 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CD358 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TNR21/ CD358/ TNFRSF21 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T64744-Ag-1 | Tumor necrosis factor receptor superfamily, member 21 (TNFRSF21) protein |
| ORF Viral Vector | vGMLP002416 | human TNFRSF21 Lentivirus particle |
| ORF Viral Vector | pGMLP002416 | human TNFRSF21 Lentivirus plasmid |
Target information
| Target ID | GM-T64744 |
| Target Name | CD358 |
| Gene ID | 27242,94185,316256,705101,609964,101090616,537922,100068460 |
| Gene Symbol and Synonyms | BM-018,CD358,DR6,TNFRSF21,TR7 |
| Uniprot Accession | O75509,D3ZF92 |
| Uniprot Entry Name | TNR21_HUMAN,TNR21_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000146072 |
| Target Classification | N/A |
The target: CD358, gene name: TNFRSF21, also named as BM-018, CD358, DR6. This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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