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Anti-STAT1 monoclonal antibody
Pre-made anti-STAT1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to STAT1/STAT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T64205-Ab-1/ GM-Tg-hg-T64205-Ab-2 | Anti-Human STAT1 monoclonal antibody | Human |
| GM-Tg-rg-T64205-Ab-1/ GM-Tg-rg-T64205-Ab-2 | Anti-Rat STAT1 monoclonal antibody | Rat |
| GM-Tg-mg-T64205-Ab-1/ GM-Tg-mg-T64205-Ab-2 | Anti-Mouse STAT1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T64205-Ab-1/ GM-Tg-cynog-T64205-Ab-2 | Anti-Cynomolgus/ Rhesus macaque STAT1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T64205-Ab-1/ GM-Tg-felg-T64205-Ab-2 | Anti-Feline STAT1 monoclonal antibody | Feline |
| GM-Tg-cang-T64205-Ab-1/ GM-Tg-cang-T64205-Ab-2 | Anti-Canine STAT1 monoclonal antibody | Canine |
| GM-Tg-bovg-T64205-Ab-1/ GM-Tg-bovg-T64205-Ab-2 | Anti-Bovine STAT1 monoclonal antibody | Bovine |
| GM-Tg-equg-T64205-Ab-1/ GM-Tg-equg-T64205-Ab-2 | Anti-Equine STAT1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T64205-Ab-1/ GM-Tg-hg-T64205-Ab-2; GM-Tg-rg-T64205-Ab-1/ GM-Tg-rg-T64205-Ab-2; GM-Tg-mg-T64205-Ab-1/ GM-Tg-mg-T64205-Ab-2; GM-Tg-cynog-T64205-Ab-1/ GM-Tg-cynog-T64205-Ab-2; GM-Tg-felg-T64205-Ab-1/ GM-Tg-felg-T64205-Ab-2; GM-Tg-cang-T64205-Ab-1/ GM-Tg-cang-T64205-Ab-2; GM-Tg-bovg-T64205-Ab-1/ GM-Tg-bovg-T64205-Ab-2; GM-Tg-equg-T64205-Ab-1/ GM-Tg-equg-T64205-Ab-2 |
| Products Name | Anti-STAT1 monoclonal antibody |
| Format | mab |
| Target Name | STAT1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-STAT1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T64205-Ag-1 | Recombinant multi-species STAT1/ CANDF7/ IMD31A protein |
| ORF Viral Vector | pGMLV000172 | human STAT1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000172 | human STAT1 Lentivirus particle |
| ORF Viral Vector | vGMAP000138 | Human STAT1 Adenovirus particle |
| ORF Viral Vector | pGMAP000138 | Human STAT1 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm004454 | mouse Stat1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004454 | mouse Stat1 Lentivirus particle |
Target information
| Target ID | GM-T64205 |
| Target Name | STAT1 |
| Gene ID | 6772,20846,25124,693650,488449,101084561,510814,100069633 |
| Gene Symbol and Synonyms | 2010005J02Rik,CANDF7,DD6G4-4,IMD31A,IMD31B,IMD31C,ISGF-3,STAT1,STAT91 |
| Uniprot Accession | P42224 |
| Uniprot Entry Name | STAT1_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000115415 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: STAT1, gene name: STAT1, also named as CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91. The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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