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Anti-TBK1 monoclonal antibody
Pre-made anti-TBK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TBK1/TBK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T63024-Ab-1/ GM-Tg-hg-T63024-Ab-2 | Anti-Human TBK1 monoclonal antibody | Human |
| GM-Tg-rg-T63024-Ab-1/ GM-Tg-rg-T63024-Ab-2 | Anti-Rat TBK1 monoclonal antibody | Rat |
| GM-Tg-mg-T63024-Ab-1/ GM-Tg-mg-T63024-Ab-2 | Anti-Mouse TBK1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T63024-Ab-1/ GM-Tg-cynog-T63024-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TBK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T63024-Ab-1/ GM-Tg-felg-T63024-Ab-2 | Anti-Feline TBK1 monoclonal antibody | Feline |
| GM-Tg-cang-T63024-Ab-1/ GM-Tg-cang-T63024-Ab-2 | Anti-Canine TBK1 monoclonal antibody | Canine |
| GM-Tg-bovg-T63024-Ab-1/ GM-Tg-bovg-T63024-Ab-2 | Anti-Bovine TBK1 monoclonal antibody | Bovine |
| GM-Tg-equg-T63024-Ab-1/ GM-Tg-equg-T63024-Ab-2 | Anti-Equine TBK1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T63024-Ab-1/ GM-Tg-hg-T63024-Ab-2; GM-Tg-rg-T63024-Ab-1/ GM-Tg-rg-T63024-Ab-2; GM-Tg-mg-T63024-Ab-1/ GM-Tg-mg-T63024-Ab-2; GM-Tg-cynog-T63024-Ab-1/ GM-Tg-cynog-T63024-Ab-2; GM-Tg-felg-T63024-Ab-1/ GM-Tg-felg-T63024-Ab-2; GM-Tg-cang-T63024-Ab-1/ GM-Tg-cang-T63024-Ab-2; GM-Tg-bovg-T63024-Ab-1/ GM-Tg-bovg-T63024-Ab-2; GM-Tg-equg-T63024-Ab-1/ GM-Tg-equg-T63024-Ab-2 |
| Products Name | Anti-TBK1 monoclonal antibody |
| Format | mab |
| Target Name | TBK1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TBK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T63024-Ag-1 | Recombinant multi-species TBK1/ FTDALS4/ IIAE8 protein |
| ORF Viral Vector | vGMLP001810 | human TBK1 Lentivirus particle |
| ORF Viral Vector | pGMLP001810 | human TBK1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004299 | mouse Tbk1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004299 | mouse Tbk1 Lentivirus particle |
Target information
| Target ID | GM-T63024 |
| Target Name | TBK1 |
| Gene ID | 29110,56480,299827,717427,481145,101091955,533141,100051650 |
| Gene Symbol and Synonyms | 1200008B05Rik,FTDALS4,IIAE8,NAK,T2K,TBK1 |
| Uniprot Accession | Q9UHD2 |
| Uniprot Entry Name | TBK1_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000183735 |
| Target Classification | Kinase |
The target: TBK1, gene name: TBK1, also named as FTDALS4, IIAE8, NAK, T2K. The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein is also an important kinase for antiviral innate immunity response. [provided by RefSeq, Sep 2021].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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