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Anti-CHK1 monoclonal antibody
Pre-made anti-CHK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to CHK1/CHEK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T62449-Ab-1/ GM-Tg-hg-T62449-Ab-2 | Anti-Human CHK1/CHEK1 monoclonal antibody | Human |
| GM-Tg-rg-T62449-Ab-1/ GM-Tg-rg-T62449-Ab-2 | Anti-Rat CHK1/CHEK1 monoclonal antibody | Rat |
| GM-Tg-mg-T62449-Ab-1/ GM-Tg-mg-T62449-Ab-2 | Anti-Mouse CHK1/CHEK1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T62449-Ab-1/ GM-Tg-cynog-T62449-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CHK1/CHEK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T62449-Ab-1/ GM-Tg-felg-T62449-Ab-2 | Anti-Feline CHK1/CHEK1 monoclonal antibody | Feline |
| GM-Tg-cang-T62449-Ab-1/ GM-Tg-cang-T62449-Ab-2 | Anti-Canine CHK1/CHEK1 monoclonal antibody | Canine |
| GM-Tg-bovg-T62449-Ab-1/ GM-Tg-bovg-T62449-Ab-2 | Anti-Bovine CHK1/CHEK1 monoclonal antibody | Bovine |
| GM-Tg-equg-T62449-Ab-1/ GM-Tg-equg-T62449-Ab-2 | Anti-Equine CHK1/CHEK1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T62449-Ab-1/ GM-Tg-hg-T62449-Ab-2; GM-Tg-rg-T62449-Ab-1/ GM-Tg-rg-T62449-Ab-2; GM-Tg-mg-T62449-Ab-1/ GM-Tg-mg-T62449-Ab-2; GM-Tg-cynog-T62449-Ab-1/ GM-Tg-cynog-T62449-Ab-2; GM-Tg-felg-T62449-Ab-1/ GM-Tg-felg-T62449-Ab-2; GM-Tg-cang-T62449-Ab-1/ GM-Tg-cang-T62449-Ab-2; GM-Tg-bovg-T62449-Ab-1/ GM-Tg-bovg-T62449-Ab-2; GM-Tg-equg-T62449-Ab-1/ GM-Tg-equg-T62449-Ab-2 |
| Products Name | Anti-CHK1/CHEK1 monoclonal antibody |
| Format | mab |
| Target Name | CHK1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-CHK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T62449-Ag-1 | Recombinant multi-species CHK1/ CHEK1 protein |
| ORF Viral Vector | pGMLP003747 | human CHEK1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003747 | human CHEK1 Lentivirus particle |
Target information
| Target ID | GM-T62449 |
| Target Name | CHK1 |
| Gene ID | 1111,12649,140583,713358,609767,101083365,513678,100064353 |
| Gene Symbol and Synonyms | CHEK1,CHK1,rad27 |
| Uniprot Accession | O14757,Q91ZN7 |
| Uniprot Entry Name | CHK1_HUMAN,CHK1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000149554 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: CHK1, gene name: CHEK1, also named as CHK1. The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from A™ and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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