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Anti-FZD10/ CD350/ FZ-10 monoclonal antibody
Anti-FZD10/ CD350/ FZ-10 antibody for FACS & in-vivo assay
Go to FZD10/FZD10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T59702-Ab-1/ GM-Tg-hg-T59702-Ab-2 | Anti-Human FZD10 monoclonal antibody | Human |
| GM-Tg-rg-T59702-Ab-1/ GM-Tg-rg-T59702-Ab-2 | Anti-Rat FZD10 monoclonal antibody | Rat |
| GM-Tg-mg-T59702-Ab-1/ GM-Tg-mg-T59702-Ab-2 | Anti-Mouse FZD10 monoclonal antibody | Mouse |
| GM-Tg-cynog-T59702-Ab-1/ GM-Tg-cynog-T59702-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FZD10 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T59702-Ab-1/ GM-Tg-felg-T59702-Ab-2 | Anti-Feline FZD10 monoclonal antibody | Feline |
| GM-Tg-cang-T59702-Ab-1/ GM-Tg-cang-T59702-Ab-2 | Anti-Canine FZD10 monoclonal antibody | Canine |
| GM-Tg-bovg-T59702-Ab-1/ GM-Tg-bovg-T59702-Ab-2 | Anti-Bovine FZD10 monoclonal antibody | Bovine |
| GM-Tg-equg-T59702-Ab-1/ GM-Tg-equg-T59702-Ab-2 | Anti-Equine FZD10 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T59702-Ab-1/ GM-Tg-hg-T59702-Ab-2; GM-Tg-rg-T59702-Ab-1/ GM-Tg-rg-T59702-Ab-2; GM-Tg-mg-T59702-Ab-1/ GM-Tg-mg-T59702-Ab-2; GM-Tg-cynog-T59702-Ab-1/ GM-Tg-cynog-T59702-Ab-2; GM-Tg-felg-T59702-Ab-1/ GM-Tg-felg-T59702-Ab-2; GM-Tg-cang-T59702-Ab-1/ GM-Tg-cang-T59702-Ab-2; GM-Tg-bovg-T59702-Ab-1/ GM-Tg-bovg-T59702-Ab-2; GM-Tg-equg-T59702-Ab-1/ GM-Tg-equg-T59702-Ab-2 |
| Products Name | Anti-FZD10 monoclonal antibody |
| Format | mab |
| Target Name | FZD10 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FZD10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-541 | Pre-Made Tabituximab biosimilar, Whole mAb ADC, Anti-FZD10 Antibody: Anti-CD350/FZ-10/Fz10/FzE7/hFz10 therapeutic antibody |
| Biosimilar | GMP-Bios-INN-1001 | Pre-Made Tabituximab Barzuxetan Biosimilar, Whole Mab Adc, Anti-Fzd10 Antibody: Anti-CD350/FZ-10/Fz10/FzE7/hFz10 therapeutic antibody Drug Conjugate |
| Target Antigen | Products Developing | Multi-species FZD10/ CD350/ FZ-10 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T59702-Ag-1 | frizzled class receptor 10 (FZD10) protein |
Target information
| Target ID | GM-T59702 |
| Target Name | FZD10 |
| Gene ID | 11211,93897,363913,717812,486232,101081169,515323,100062909 |
| Gene Symbol and Synonyms | CD350,FZ-10,Fz10,FZD10,Fzd10-ps1,FzE7,hFz10 |
| Uniprot Accession | Q9ULW2 |
| Uniprot Entry Name | FZD10_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000111432 |
| Target Classification | GPCR |
The target: FZD10, gene name: FZD10, also named as CD350, FZ-10, Fz10, FzE7, hFz10. This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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