Anti-GP183/ GPR183/ EBI2 monoclonal antibody

Anti-GP183/ GPR183/ EBI2 antibody for FACS & in-vivo assay

Target products collectionGo to GPR183/GPR183 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T59577-Ab-1/ GM-Tg-hg-T59577-Ab-2Anti-Human GPR183 monoclonal antibodyHuman
GM-Tg-rg-T59577-Ab-1/ GM-Tg-rg-T59577-Ab-2Anti-Rat GPR183 monoclonal antibodyRat
GM-Tg-mg-T59577-Ab-1/ GM-Tg-mg-T59577-Ab-2Anti-Mouse GPR183 monoclonal antibodyMouse
GM-Tg-cynog-T59577-Ab-1/ GM-Tg-cynog-T59577-Ab-2Anti-Cynomolgus/ Rhesus macaque GPR183 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T59577-Ab-1/ GM-Tg-felg-T59577-Ab-2Anti-Feline GPR183 monoclonal antibodyFeline
GM-Tg-cang-T59577-Ab-1/ GM-Tg-cang-T59577-Ab-2Anti-Canine GPR183 monoclonal antibodyCanine
GM-Tg-bovg-T59577-Ab-1/ GM-Tg-bovg-T59577-Ab-2Anti-Bovine GPR183 monoclonal antibodyBovine
GM-Tg-equg-T59577-Ab-1/ GM-Tg-equg-T59577-Ab-2Anti-Equine GPR183 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T59577-Ab-1/ GM-Tg-hg-T59577-Ab-2; GM-Tg-rg-T59577-Ab-1/ GM-Tg-rg-T59577-Ab-2;
GM-Tg-mg-T59577-Ab-1/ GM-Tg-mg-T59577-Ab-2; GM-Tg-cynog-T59577-Ab-1/ GM-Tg-cynog-T59577-Ab-2;
GM-Tg-felg-T59577-Ab-1/ GM-Tg-felg-T59577-Ab-2; GM-Tg-cang-T59577-Ab-1/ GM-Tg-cang-T59577-Ab-2;
GM-Tg-bovg-T59577-Ab-1/ GM-Tg-bovg-T59577-Ab-2; GM-Tg-equg-T59577-Ab-1/ GM-Tg-equg-T59577-Ab-2
Products NameAnti-GPR183 monoclonal antibody
Formatmab
Target NameGPR183
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GPR183 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species GP183/ GPR183/ EBI2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP003788human GPR183 Lentivirus plasmid
    ORF Viral VectorvGMLP003788human GPR183 Lentivirus particle


    Target information

    Target IDGM-T59577
    Target NameGPR183
    Gene ID1880,321019,679975,698844,540287,100050745
    Gene Symbol and SynonymsEBI2,GPR183,hEBI2
    Uniprot AccessionP32249,D4A7K7,Q1RMI1
    Uniprot Entry NameGP183_HUMAN,GP183_RAT,GP183_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000169508
    Target ClassificationGPCR

    The target: GPR183, gene name: GPR183, also named as EBI2, hEBI2. This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.