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Anti-MPRI/ IGF2R/ CD222 monoclonal antibody
Anti-MPRI/ IGF2R/ CD222 antibody for FACS & in-vivo assay
Go to IGF2R/IGF2R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T59550-Ab-1/ GM-Tg-hg-T59550-Ab-2 | Anti-Human IGF2R monoclonal antibody | Human |
| GM-Tg-rg-T59550-Ab-1/ GM-Tg-rg-T59550-Ab-2 | Anti-Rat IGF2R monoclonal antibody | Rat |
| GM-Tg-mg-T59550-Ab-1/ GM-Tg-mg-T59550-Ab-2 | Anti-Mouse IGF2R monoclonal antibody | Mouse |
| GM-Tg-cynog-T59550-Ab-1/ GM-Tg-cynog-T59550-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IGF2R monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T59550-Ab-1/ GM-Tg-felg-T59550-Ab-2 | Anti-Feline IGF2R monoclonal antibody | Feline |
| GM-Tg-cang-T59550-Ab-1/ GM-Tg-cang-T59550-Ab-2 | Anti-Canine IGF2R monoclonal antibody | Canine |
| GM-Tg-bovg-T59550-Ab-1/ GM-Tg-bovg-T59550-Ab-2 | Anti-Bovine IGF2R monoclonal antibody | Bovine |
| GM-Tg-equg-T59550-Ab-1/ GM-Tg-equg-T59550-Ab-2 | Anti-Equine IGF2R monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T59550-Ab-1/ GM-Tg-hg-T59550-Ab-2; GM-Tg-rg-T59550-Ab-1/ GM-Tg-rg-T59550-Ab-2; GM-Tg-mg-T59550-Ab-1/ GM-Tg-mg-T59550-Ab-2; GM-Tg-cynog-T59550-Ab-1/ GM-Tg-cynog-T59550-Ab-2; GM-Tg-felg-T59550-Ab-1/ GM-Tg-felg-T59550-Ab-2; GM-Tg-cang-T59550-Ab-1/ GM-Tg-cang-T59550-Ab-2; GM-Tg-bovg-T59550-Ab-1/ GM-Tg-bovg-T59550-Ab-2; GM-Tg-equg-T59550-Ab-1/ GM-Tg-equg-T59550-Ab-2 |
| Products Name | Anti-IGF2R monoclonal antibody |
| Format | mab |
| Target Name | IGF2R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IGF2R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MPRI/ IGF2R/ CD222 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T59550-Ag-1 | insulin-like growth factor 2 receptor (IGF2R) protein |
Target information
| Target ID | GM-T59550 |
| Target Name | IGF2R |
| Gene ID | 3482,16004,25151,703220,484067,100500935,281849,100058539 |
| Gene Symbol and Synonyms | CD222,CI-M6PR,CI-MPR,CIMPR,IGF-IIR,IGF2R,Igfr2,M6P-R,M6P/IGF2R,MPR 300,MPR1,MPR300,MPRI |
| Uniprot Accession | P11717,P08169 |
| Uniprot Entry Name | MPRI_HUMAN,MPRI_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000197081 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: IGF2R, gene name: IGF2R, also named as CD222, CI-M6PR, CIMPR, M6P-R, M6P/IGF2R, MPR 300, MPR1, MPR300, MPRI. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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