Anti-FCG3A/ FCGR3A/ CD16 monoclonal antibody

Anti-FCG3A/ FCGR3A/ CD16 antibody for FACS & in-vivo assay

Target products collectionGo to FCGR3A/FCGR3A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T59001-Ab-1/ GM-Tg-hg-T59001-Ab-2 Anti-Human FCGR3A monoclonal antibody Human
GM-Tg-hg-T59001-Ab-3/ GM-Tg-hg-T59001-Ab-4 Anti-Human FCGR3A monoclonal antibody Human
GM-Tg-rg-T59001-Ab-1/ GM-Tg-rg-T59001-Ab-2 Anti-Rat FCGR3A monoclonal antibody Rat
GM-Tg-mg-T59001-Ab-1/ GM-Tg-mg-T59001-Ab-2 Anti-Mouse FCGR3A monoclonal antibody Mouse
GM-Tg-cynog-T59001-Ab-1/ GM-Tg-cynog-T59001-Ab-2 Anti-Cynomolgus/ Rhesus macaque FCGR3A monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T59001-Ab-1/ GM-Tg-felg-T59001-Ab-2 Anti-Feline FCGR3A monoclonal antibody Feline
GM-Tg-cang-T59001-Ab-1/ GM-Tg-cang-T59001-Ab-2 Anti-Canine FCGR3A monoclonal antibody Canine
GM-Tg-bovg-T59001-Ab-1/ GM-Tg-bovg-T59001-Ab-2 Anti-Bovine FCGR3A monoclonal antibody Bovine
GM-Tg-equg-T59001-Ab-1/ GM-Tg-equg-T59001-Ab-2 Anti-Equine FCGR3A monoclonal antibody Equine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T59001-Ab-1/ GM-Tg-hg-T59001-Ab-2; GM-Tg-hg-T59001-Ab-3/ GM-Tg-hg-T59001-Ab-4; GM-Tg-rg-T59001-Ab-1/ GM-Tg-rg-T59001-Ab-2;
GM-Tg-mg-T59001-Ab-1/ GM-Tg-mg-T59001-Ab-2; GM-Tg-cynog-T59001-Ab-1/ GM-Tg-cynog-T59001-Ab-2;
GM-Tg-felg-T59001-Ab-1/ GM-Tg-felg-T59001-Ab-2; GM-Tg-cang-T59001-Ab-1/ GM-Tg-cang-T59001-Ab-2;
GM-Tg-bovg-T59001-Ab-1/ GM-Tg-bovg-T59001-Ab-2; GM-Tg-equg-T59001-Ab-1/ GM-Tg-equg-T59001-Ab-2
Products Name Anti-FCGR3A monoclonal antibody
Format mab
Target Name FCGR3A
Protein Sub-location Transmembrane Protein
Category of antibody FACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species) Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC) N/A
Expression platform Mammalian Expression
Bioactivity validation Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
Tag Fc
Products description Pre-made anti-FCGR3A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    Category Cat No. Products Name
    Target Antigen Products Developing Multi-species FCG3A/ FCGR3A/ CD16 VLP (virus-like particle) (Products Developing)
    ORF Viral Vector vGMLP005178 human FCGR3A Lentivirus particle
    ORF Viral Vector pGMLP003289 human FCGR3A Lentivirus plasmid
    ORF Viral Vector vGMLP003289 human FCGR3A Lentivirus particle
    ORF Viral Vector pGMLP005178 human FCGR3A Lentivirus plasmid


    Target information

    Target ID GM-T59001
    Target Name FCGR3A
    Gene ID 2214,493677
    Gene Symbol and Synonyms CD16,CD16-II,CD16A,FCG3,FCGR3,FCGR3A,FCGRIII,FcGRIIIA,FCR-10,FCRIII,FCRIIIA,IGFR3,IMD20
    Uniprot Accession P08637,Q9N2I5
    Uniprot Entry Name FCG3A_HUMAN,FCG3A_FELCA
    Protein Sub-location Transmembrane Protein
    Category Therapeutics Target, Immuno-oncology Target
    Disease Cancer
    Gene Ensembl ENSG00000203747
    Target Classification Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)

    The target: FCGR3A, gene name: FCGR3A, also named as CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20. This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.