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Anti-APEL/ Apelin/ APLN functional antibody
Anti-APEL/ Apelin/ APLN functional antibody for cell culture, ELISA & in-vivo assay
Go to Apelin/APLN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T58674-Ab-1/ GM-Tg-hg-T58674-Ab-2 | Anti-Human Apelin/APLN monoclonal antibody | Human |
| GM-Tg-rg-T58674-Ab-1/ GM-Tg-rg-T58674-Ab-2 | Anti-Rat Apelin/APLN monoclonal antibody | Rat |
| GM-Tg-mg-T58674-Ab-1/ GM-Tg-mg-T58674-Ab-2 | Anti-Mouse Apelin/APLN monoclonal antibody | Mouse |
| GM-Tg-cynog-T58674-Ab-1/ GM-Tg-cynog-T58674-Ab-2 | Anti-Cynomolgus/ Rhesus macaque Apelin/APLN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T58674-Ab-1/ GM-Tg-felg-T58674-Ab-2 | Anti-Feline Apelin/APLN monoclonal antibody | Feline |
| GM-Tg-cang-T58674-Ab-1/ GM-Tg-cang-T58674-Ab-2 | Anti-Canine Apelin/APLN monoclonal antibody | Canine |
| GM-Tg-bovg-T58674-Ab-1/ GM-Tg-bovg-T58674-Ab-2 | Anti-Bovine Apelin/APLN monoclonal antibody | Bovine |
| GM-Tg-equg-T58674-Ab-1/ GM-Tg-equg-T58674-Ab-2 | Anti-Equine Apelin/APLN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T58674-Ab-1/ GM-Tg-hg-T58674-Ab-2; GM-Tg-rg-T58674-Ab-1/ GM-Tg-rg-T58674-Ab-2; GM-Tg-mg-T58674-Ab-1/ GM-Tg-mg-T58674-Ab-2; GM-Tg-cynog-T58674-Ab-1/ GM-Tg-cynog-T58674-Ab-2; GM-Tg-felg-T58674-Ab-1/ GM-Tg-felg-T58674-Ab-2; GM-Tg-cang-T58674-Ab-1/ GM-Tg-cang-T58674-Ab-2; GM-Tg-bovg-T58674-Ab-1/ GM-Tg-bovg-T58674-Ab-2; GM-Tg-equg-T58674-Ab-1/ GM-Tg-equg-T58674-Ab-2 |
| Products Name | Anti-Apelin/APLN monoclonal antibody |
| Format | mab |
| Target Name | Apelin |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-Apelin benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T58674-Ag-1 | Recombinant multi-species APEL/ Apelin/ APLN protein |
| Cytokine | GM-Tg-g-T58674-Ag-1 | apelin (APLN) protein |
| ORF Viral Vector | pGMLP004562 | human APLN Lentivirus plasmid |
| ORF Viral Vector | vGMLP004562 | human APLN Lentivirus particle |
| ORF Viral Vector | pGMAD000266 | mouse Apln Adenovirus plasmid |
| ORF Viral Vector | vGMAD000266 | mouse Apln Adenovirus particle |
Target information
| Target ID | GM-T58674 |
| Target Name | Apelin |
| Gene ID | 8862,30878,58812,702695,611497,101101295,282143,102149746 |
| Gene Symbol and Synonyms | 6030430G11Rik,APEL,APLN,XNPEP2 |
| Uniprot Accession | Q9ULZ1,Q9R0R3,Q9TUI9 |
| Uniprot Entry Name | APEL_HUMAN,APEL_RAT,APEL_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000171388 |
| Target Classification | N/A |
The target: Apelin, gene name: APLN, also named as APEL, XNPEP2. This gene encodes a peptide that functions as an endogenous ligand for the G-protein coupled apelin receptor. The encoded preproprotein is proteolytically processed into biologically active C-terminal peptide fragments. These peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. [provided by RefSeq, Feb 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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