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Anti-EPHA8/ EEK/ EK3 monoclonal antibody
Anti-EPHA8/ EEK/ EK3 antibody for FACS & in-vivo assay
Go to EPHA8/EPHA8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T58266-Ab-1/ GM-Tg-hg-T58266-Ab-2 | Anti-Human EPHA8 monoclonal antibody | Human |
| GM-Tg-rg-T58266-Ab-1/ GM-Tg-rg-T58266-Ab-2 | Anti-Rat EPHA8 monoclonal antibody | Rat |
| GM-Tg-mg-T58266-Ab-1/ GM-Tg-mg-T58266-Ab-2 | Anti-Mouse EPHA8 monoclonal antibody | Mouse |
| GM-Tg-cynog-T58266-Ab-1/ GM-Tg-cynog-T58266-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EPHA8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T58266-Ab-1/ GM-Tg-felg-T58266-Ab-2 | Anti-Feline EPHA8 monoclonal antibody | Feline |
| GM-Tg-cang-T58266-Ab-1/ GM-Tg-cang-T58266-Ab-2 | Anti-Canine EPHA8 monoclonal antibody | Canine |
| GM-Tg-bovg-T58266-Ab-1/ GM-Tg-bovg-T58266-Ab-2 | Anti-Bovine EPHA8 monoclonal antibody | Bovine |
| GM-Tg-equg-T58266-Ab-1/ GM-Tg-equg-T58266-Ab-2 | Anti-Equine EPHA8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T58266-Ab-1/ GM-Tg-hg-T58266-Ab-2; GM-Tg-rg-T58266-Ab-1/ GM-Tg-rg-T58266-Ab-2; GM-Tg-mg-T58266-Ab-1/ GM-Tg-mg-T58266-Ab-2; GM-Tg-cynog-T58266-Ab-1/ GM-Tg-cynog-T58266-Ab-2; GM-Tg-felg-T58266-Ab-1/ GM-Tg-felg-T58266-Ab-2; GM-Tg-cang-T58266-Ab-1/ GM-Tg-cang-T58266-Ab-2; GM-Tg-bovg-T58266-Ab-1/ GM-Tg-bovg-T58266-Ab-2; GM-Tg-equg-T58266-Ab-1/ GM-Tg-equg-T58266-Ab-2 |
| Products Name | Anti-EPHA8 monoclonal antibody |
| Format | mab |
| Target Name | EPHA8 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EPHA8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species EPHA8/ EEK/ EK3 VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T58266 |
| Target Name | EPHA8 |
| Gene ID | 2046,13842,60589,708378,487383,101095669,517368,100071673 |
| Gene Symbol and Synonyms | EEK,EK3,EPHA8,HEK3,mKIAA1459 |
| Uniprot Accession | P29322,P29321 |
| Uniprot Entry Name | EPHA8_HUMAN,EPHA8_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000070886 |
| Target Classification | Kinase |
The target: EPHA8, gene name: EPHA8, also named as EEK, EK3, HEK3. This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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