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Anti-CXCR2/ CD182/ CDw128b monoclonal antibody
Anti-CXCR2/ CD182/ CDw128b antibody for FACS & in-vivo assay
Go to CXCR2/CXCR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T56923-Ab-1/ GM-Tg-hg-T56923-Ab-2 | Anti-Human CXCR2 monoclonal antibody | Human |
| GM-Tg-rg-T56923-Ab-1/ GM-Tg-rg-T56923-Ab-2 | Anti-Rat CXCR2 monoclonal antibody | Rat |
| GM-Tg-mg-T56923-Ab-1/ GM-Tg-mg-T56923-Ab-2 | Anti-Mouse CXCR2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T56923-Ab-1/ GM-Tg-cynog-T56923-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CXCR2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T56923-Ab-1/ GM-Tg-felg-T56923-Ab-2 | Anti-Feline CXCR2 monoclonal antibody | Feline |
| GM-Tg-cang-T56923-Ab-1/ GM-Tg-cang-T56923-Ab-2 | Anti-Canine CXCR2 monoclonal antibody | Canine |
| GM-Tg-bovg-T56923-Ab-1/ GM-Tg-bovg-T56923-Ab-2 | Anti-Bovine CXCR2 monoclonal antibody | Bovine |
| GM-Tg-equg-T56923-Ab-1/ GM-Tg-equg-T56923-Ab-2 | Anti-Equine CXCR2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T56923-Ab-1/ GM-Tg-hg-T56923-Ab-2; GM-Tg-rg-T56923-Ab-1/ GM-Tg-rg-T56923-Ab-2; GM-Tg-mg-T56923-Ab-1/ GM-Tg-mg-T56923-Ab-2; GM-Tg-cynog-T56923-Ab-1/ GM-Tg-cynog-T56923-Ab-2; GM-Tg-felg-T56923-Ab-1/ GM-Tg-felg-T56923-Ab-2; GM-Tg-cang-T56923-Ab-1/ GM-Tg-cang-T56923-Ab-2; GM-Tg-bovg-T56923-Ab-1/ GM-Tg-bovg-T56923-Ab-2; GM-Tg-equg-T56923-Ab-1/ GM-Tg-equg-T56923-Ab-2 |
| Products Name | Anti-CXCR2 monoclonal antibody |
| Format | mab |
| Target Name | CXCR2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CXCR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CXCR2/ CD182/ CDw128b VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T56923-Ag-1 | chemokine (C-X-C motif) receptor 2 (CXCR2) protein |
| ORF Viral Vector | vGMLP001481 | human CXCR2 Lentivirus particle |
| ORF Viral Vector | pGMLP001481 | human CXCR2 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000786 | house mouse Cxcr2 Lentivirus plasmid |
| ORF Viral Vector | pGMAAV000045 | mouse Cxcr2 AAV plasmid |
| ORF Viral Vector | vGMLV000786 | house mouse Cxcr2 Lentivirus particle |
| ORF Viral Vector | vGMAAV000045 | mouse Cxcr2 AAV particle |
Target information
| Target ID | GM-T56923 |
| Target Name | CXCR2 |
| Gene ID | 3579,12765,29385,700407,478905,101085396,782719,100055552 |
| Gene Symbol and Synonyms | CD128,CD182,CDw128,CDw128b,CMKAR2,CXC-R2,CXCR-2,CXCR2,Gpcr16,IL-8rb,IL-8Rh,IL8R2,IL8RA,IL8RB,mIL-8RH,WHIMS2 |
| Uniprot Accession | P25025,P35407,Q28519,O97571 |
| Uniprot Entry Name | CXCR2_HUMAN,CXCR2_MACMU,CXCR2_RAT,CXCR2_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000180871 |
| Target Classification | Checkpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA) |
The target: CXCR2, gene name: CXCR2, also named as CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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