Anti-KDM5B monoclonal antibody

Pre-made anti-KDM5B monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to KDM5B/KDM5B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T56871-Ab-1/ GM-Tg-hg-T56871-Ab-2Anti-Human KDM5B monoclonal antibodyHuman
GM-Tg-rg-T56871-Ab-1/ GM-Tg-rg-T56871-Ab-2Anti-Rat KDM5B monoclonal antibodyRat
GM-Tg-mg-T56871-Ab-1/ GM-Tg-mg-T56871-Ab-2Anti-Mouse KDM5B monoclonal antibodyMouse
GM-Tg-cynog-T56871-Ab-1/ GM-Tg-cynog-T56871-Ab-2Anti-Cynomolgus/ Rhesus macaque KDM5B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T56871-Ab-1/ GM-Tg-felg-T56871-Ab-2Anti-Feline KDM5B monoclonal antibodyFeline
GM-Tg-cang-T56871-Ab-1/ GM-Tg-cang-T56871-Ab-2Anti-Canine KDM5B monoclonal antibodyCanine
GM-Tg-bovg-T56871-Ab-1/ GM-Tg-bovg-T56871-Ab-2Anti-Bovine KDM5B monoclonal antibodyBovine
GM-Tg-equg-T56871-Ab-1/ GM-Tg-equg-T56871-Ab-2Anti-Equine KDM5B monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T56871-Ab-1/ GM-Tg-hg-T56871-Ab-2; GM-Tg-rg-T56871-Ab-1/ GM-Tg-rg-T56871-Ab-2;
GM-Tg-mg-T56871-Ab-1/ GM-Tg-mg-T56871-Ab-2; GM-Tg-cynog-T56871-Ab-1/ GM-Tg-cynog-T56871-Ab-2;
GM-Tg-felg-T56871-Ab-1/ GM-Tg-felg-T56871-Ab-2; GM-Tg-cang-T56871-Ab-1/ GM-Tg-cang-T56871-Ab-2;
GM-Tg-bovg-T56871-Ab-1/ GM-Tg-bovg-T56871-Ab-2; GM-Tg-equg-T56871-Ab-1/ GM-Tg-equg-T56871-Ab-2
Products NameAnti-KDM5B monoclonal antibody
Formatmab
Target NameKDM5B
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-KDM5B monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T56871-Ag-1Recombinant multi-species KDM5B/ CT31/ JARID1B protein


    Target information

    Target IDGM-T56871
    Target NameKDM5B
    Gene ID10765,75605,304809,706437,479999,101101609,540633,100064707
    Gene Symbol and Synonyms2010009J12Rik,2210016I17Rik,CT31,D1Ertd202e,JARID1B,KDM5B,mKIAA4034,MRT65,PLU-1,PLU1,PPP1R98,PUT1,Rb-Bp2,RBBP2H1A,RBP2-H1,RGD1565602
    Uniprot AccessionQ9UGL1
    Uniprot Entry NameKDM5B_HUMAN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000117139
    Target ClassificationN/A

    The target: KDM5B, gene name: KDM5B, also named as CT31, JARID1B, MRT65, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A, RBP2-H1. This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.