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Anti-ABCG2/ ABC15/ ABCP monoclonal antibody
Anti-ABCG2/ ABC15/ ABCP antibody for FACS & in-vivo assay
Go to ABCG2/ABCG2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T56556-Ab-1/ GM-Tg-hg-T56556-Ab-2 | Anti-Human ABCG2 monoclonal antibody | Human |
| GM-Tg-rg-T56556-Ab-1/ GM-Tg-rg-T56556-Ab-2 | Anti-Rat ABCG2 monoclonal antibody | Rat |
| GM-Tg-mg-T56556-Ab-1/ GM-Tg-mg-T56556-Ab-2 | Anti-Mouse ABCG2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T56556-Ab-1/ GM-Tg-cynog-T56556-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ABCG2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T56556-Ab-1/ GM-Tg-felg-T56556-Ab-2 | Anti-Feline ABCG2 monoclonal antibody | Feline |
| GM-Tg-cang-T56556-Ab-1/ GM-Tg-cang-T56556-Ab-2 | Anti-Canine ABCG2 monoclonal antibody | Canine |
| GM-Tg-bovg-T56556-Ab-1/ GM-Tg-bovg-T56556-Ab-2 | Anti-Bovine ABCG2 monoclonal antibody | Bovine |
| GM-Tg-equg-T56556-Ab-1/ GM-Tg-equg-T56556-Ab-2 | Anti-Equine ABCG2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T56556-Ab-1/ GM-Tg-hg-T56556-Ab-2; GM-Tg-rg-T56556-Ab-1/ GM-Tg-rg-T56556-Ab-2; GM-Tg-mg-T56556-Ab-1/ GM-Tg-mg-T56556-Ab-2; GM-Tg-cynog-T56556-Ab-1/ GM-Tg-cynog-T56556-Ab-2; GM-Tg-felg-T56556-Ab-1/ GM-Tg-felg-T56556-Ab-2; GM-Tg-cang-T56556-Ab-1/ GM-Tg-cang-T56556-Ab-2; GM-Tg-bovg-T56556-Ab-1/ GM-Tg-bovg-T56556-Ab-2; GM-Tg-equg-T56556-Ab-1/ GM-Tg-equg-T56556-Ab-2 |
| Products Name | Anti-ABCG2 monoclonal antibody |
| Format | mab |
| Target Name | ABCG2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ABCG2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ABCG2/ ABC15/ ABCP VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000861 | human ABCG2 Lentivirus particle |
| ORF Viral Vector | pGMLV000862 | human ABCG2 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000231 | human ABCG2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000862 | human ABCG2 Lentivirus particle |
| ORF Viral Vector | pGMLV000861 | human ABCG2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000231 | human ABCG2 Lentivirus particle |
| ORF Viral Vector | pGMAAV000265 | Norway rat Abcg2 AAV plasmid |
| ORF Viral Vector | vGMAAV000265 | Norway rat Abcg2 AAV particle |
Target information
| Target ID | GM-T56556 |
| Target Name | ABCG2 |
| Gene ID | 9429,26357,312382,574307,478472,101094017,536203,100034164 |
| Gene Symbol and Synonyms | ABC15,ABCG2,ABCG3,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,CDw388,EST157481,GOUT1,MRX,MXR,MXR-1,MXR1,UAQTL1 |
| Uniprot Accession | Q9UNQ0,Q80W57,Q5MB13,Q4GZT4 |
| Uniprot Entry Name | ABCG2_HUMAN,ABCG2_MACMU,ABCG2_RAT,ABCG2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000118777 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ABCG2, gene name: ABCG2, also named as ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR-1, MXR1, UAQTL1. The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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