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Anti-EPHB3/ EK2/ ETK2 monoclonal antibody
Anti-EPHB3/ EK2/ ETK2 antibody for FACS & in-vivo assay
Go to EPHB3/EPHB3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T56121-Ab-1/ GM-Tg-hg-T56121-Ab-2 | Anti-Human EPHB3 monoclonal antibody | Human |
| GM-Tg-rg-T56121-Ab-1/ GM-Tg-rg-T56121-Ab-2 | Anti-Rat EPHB3 monoclonal antibody | Rat |
| GM-Tg-mg-T56121-Ab-1/ GM-Tg-mg-T56121-Ab-2 | Anti-Mouse EPHB3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T56121-Ab-1/ GM-Tg-cynog-T56121-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EPHB3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T56121-Ab-1/ GM-Tg-felg-T56121-Ab-2 | Anti-Feline EPHB3 monoclonal antibody | Feline |
| GM-Tg-cang-T56121-Ab-1/ GM-Tg-cang-T56121-Ab-2 | Anti-Canine EPHB3 monoclonal antibody | Canine |
| GM-Tg-bovg-T56121-Ab-1/ GM-Tg-bovg-T56121-Ab-2 | Anti-Bovine EPHB3 monoclonal antibody | Bovine |
| GM-Tg-equg-T56121-Ab-1/ GM-Tg-equg-T56121-Ab-2 | Anti-Equine EPHB3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T56121-Ab-1/ GM-Tg-hg-T56121-Ab-2; GM-Tg-rg-T56121-Ab-1/ GM-Tg-rg-T56121-Ab-2; GM-Tg-mg-T56121-Ab-1/ GM-Tg-mg-T56121-Ab-2; GM-Tg-cynog-T56121-Ab-1/ GM-Tg-cynog-T56121-Ab-2; GM-Tg-felg-T56121-Ab-1/ GM-Tg-felg-T56121-Ab-2; GM-Tg-cang-T56121-Ab-1/ GM-Tg-cang-T56121-Ab-2; GM-Tg-bovg-T56121-Ab-1/ GM-Tg-bovg-T56121-Ab-2; GM-Tg-equg-T56121-Ab-1/ GM-Tg-equg-T56121-Ab-2 |
| Products Name | Anti-EPHB3 monoclonal antibody |
| Format | mab |
| Target Name | EPHB3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EPHB3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species EPHB3/ EK2/ ETK2 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001496 | human EpGM3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001496 | human EvGM3 Lentivirus particle |
Target information
| Target ID | GM-T56121 |
| Target Name | EPHB3 |
| Gene ID | 2049,13845,287989,701811,488108,101094200,540907,100067381 |
| Gene Symbol and Synonyms | Cek10,EK2,EPHB3,ETK2,HEK2,mDK-5,MDK5,Sek4,TYRO6 |
| Uniprot Accession | P54753 |
| Uniprot Entry Name | EPHB3_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000182580 |
| Target Classification | N/A |
The target: EPHB3, gene name: EPHB3, also named as EK2, ETK2, HEK2, TYRO6. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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