Anti-RET4/ RBP4/ MCOPCB10 functional antibody

Anti-RET4/ RBP4/ MCOPCB10 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to RBP4/RBP4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T55703-Ab-1/ GM-Tg-hg-T55703-Ab-2Anti-Human RBP4 monoclonal antibodyHuman
GM-Tg-rg-T55703-Ab-1/ GM-Tg-rg-T55703-Ab-2Anti-Rat RBP4 monoclonal antibodyRat
GM-Tg-mg-T55703-Ab-1/ GM-Tg-mg-T55703-Ab-2Anti-Mouse RBP4 monoclonal antibodyMouse
GM-Tg-cynog-T55703-Ab-1/ GM-Tg-cynog-T55703-Ab-2Anti-Cynomolgus/ Rhesus macaque RBP4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T55703-Ab-1/ GM-Tg-felg-T55703-Ab-2Anti-Feline RBP4 monoclonal antibodyFeline
GM-Tg-cang-T55703-Ab-1/ GM-Tg-cang-T55703-Ab-2Anti-Canine RBP4 monoclonal antibodyCanine
GM-Tg-bovg-T55703-Ab-1/ GM-Tg-bovg-T55703-Ab-2Anti-Bovine RBP4 monoclonal antibodyBovine
GM-Tg-equg-T55703-Ab-1/ GM-Tg-equg-T55703-Ab-2Anti-Equine RBP4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T55703-Ab-1/ GM-Tg-hg-T55703-Ab-2; GM-Tg-rg-T55703-Ab-1/ GM-Tg-rg-T55703-Ab-2;
GM-Tg-mg-T55703-Ab-1/ GM-Tg-mg-T55703-Ab-2; GM-Tg-cynog-T55703-Ab-1/ GM-Tg-cynog-T55703-Ab-2;
GM-Tg-felg-T55703-Ab-1/ GM-Tg-felg-T55703-Ab-2; GM-Tg-cang-T55703-Ab-1/ GM-Tg-cang-T55703-Ab-2;
GM-Tg-bovg-T55703-Ab-1/ GM-Tg-bovg-T55703-Ab-2; GM-Tg-equg-T55703-Ab-1/ GM-Tg-equg-T55703-Ab-2
Products NameAnti-RBP4 monoclonal antibody
Formatmab
Target NameRBP4
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-RBP4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T55703-Ag-1Recombinant multi-species RET4/ RBP4/ MCOPCB10 protein
    CytokineGM-Tg-g-T55703-Ag-1retinol binding protein 4 (RBP4) protein
    ORF Viral VectorpGMLP001901human RBP4 Lentivirus plasmid
    ORF Viral VectorvGMLP001901human RBP4 Lentivirus particle
    ORF Viral VectorpGMAD000074mouse Rbp4 Adenovirus plasmid
    ORF Viral VectorvGMAD000074mouse Rbp4 Adenovirus particle


    Target information

    Target IDGM-T55703
    Target NameRBP4
    Gene ID5950,19662,25703,701270,477775,101094377,281444
    Gene Symbol and SynonymsfCP1,MCOPCB10,PRBP,RBP,Rbp-4,RBP4,RBPA,RDCCAS
    Uniprot AccessionP02753,P04916,M5AXY1,P18902
    Uniprot Entry NameRET4_HUMAN,RET4_RAT,RET4_FELCA,RET4_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Diagnostics Biomarker, Cytokine Target
    DiseaseLung Cancer, Complications of kidney transplant, Acute kidney failure, Chronic Kidney Disease, Dent disease, Diabetic Nephropathy, Nephrotic syndrome, Nephrotic syndrome with focal and segmental glomerular lesions, Perinatal necrotizing enterocolitis, Type 1 diabetes mellitus, Type 2 diabetes mellitus
    Gene EnsemblENSG00000138207
    Target ClassificationN/A

    The target: RBP4, gene name: RBP4, also named as MCOPCB10, RDCCAS. This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.