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Anti-MMP9/ MMP-9/ CLG4B functional antibody
Anti-MMP9/ MMP-9/ CLG4B functional antibody for cell culture, ELISA & in-vivo assay
Go to MMP-9/MMP9 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T54156-Ab-1/ GM-Tg-hg-T54156-Ab-2 | Anti-Human MMP-9/MMP9 monoclonal antibody | Human |
| GM-Tg-rg-T54156-Ab-1/ GM-Tg-rg-T54156-Ab-2 | Anti-Rat MMP-9/MMP9 monoclonal antibody | Rat |
| GM-Tg-mg-T54156-Ab-1/ GM-Tg-mg-T54156-Ab-2 | Anti-Mouse MMP-9/MMP9 monoclonal antibody | Mouse |
| GM-Tg-cynog-T54156-Ab-1/ GM-Tg-cynog-T54156-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MMP-9/MMP9 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T54156-Ab-1/ GM-Tg-felg-T54156-Ab-2 | Anti-Feline MMP-9/MMP9 monoclonal antibody | Feline |
| GM-Tg-cang-T54156-Ab-1/ GM-Tg-cang-T54156-Ab-2 | Anti-Canine MMP-9/MMP9 monoclonal antibody | Canine |
| GM-Tg-bovg-T54156-Ab-1/ GM-Tg-bovg-T54156-Ab-2 | Anti-Bovine MMP-9/MMP9 monoclonal antibody | Bovine |
| GM-Tg-equg-T54156-Ab-1/ GM-Tg-equg-T54156-Ab-2 | Anti-Equine MMP-9/MMP9 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T54156-Ab-1/ GM-Tg-hg-T54156-Ab-2; GM-Tg-rg-T54156-Ab-1/ GM-Tg-rg-T54156-Ab-2; GM-Tg-mg-T54156-Ab-1/ GM-Tg-mg-T54156-Ab-2; GM-Tg-cynog-T54156-Ab-1/ GM-Tg-cynog-T54156-Ab-2; GM-Tg-felg-T54156-Ab-1/ GM-Tg-felg-T54156-Ab-2; GM-Tg-cang-T54156-Ab-1/ GM-Tg-cang-T54156-Ab-2; GM-Tg-bovg-T54156-Ab-1/ GM-Tg-bovg-T54156-Ab-2; GM-Tg-equg-T54156-Ab-1/ GM-Tg-equg-T54156-Ab-2 |
| Products Name | Anti-MMP-9/MMP9 monoclonal antibody |
| Format | mab |
| Target Name | MMP-9 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MMP-9 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-024 | Pre-Made Andecaliximab biosimilar, Whole mAb, Anti-MMP9/MMP-9 Antibody: Anti-CLG4B/GELB/MANDP2 therapeutic antibody |
| Target Antigen | GM-Tg-g-T54156-Ag-1 | Recombinant multi-species MMP9/ MMP-9/ CLG4B protein |
| ORF Viral Vector | pGMAP000473 | Human MMP9 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000473 | Human MMP9 Adenovirus particle |
Target information
| Target ID | GM-T54156 |
| Target Name | MMP-9 |
| Gene ID | 4318,17395,81687,708084,403885,101084185,282871,100056599 |
| Gene Symbol and Synonyms | B/MMP9,CLG4B,Gel B,GELB,MANDP2,MMP-9,MMP9,pro-MMP-9 |
| Uniprot Accession | P14780,P50282,O18733,P52176 |
| Uniprot Entry Name | MMP9_HUMAN,MMP9_RAT,MMP9_CANLF,MMP9_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index |
| Disease | Breast Cancer, Malignant neoplasm of bladder, Renal cell carcinoma, Neoplasm, Hemangioma, Malignant neoplasms of female genital organs, Alport syndrome, Calculus of kidney, Chronic Kidney Disease, Chronic tubulo-interstitial nephritis, Congenital occlusion of ureteropelvic junction |
| Gene Ensembl | ENSG00000100985 |
| Target Classification | N/A |
The target: MMP-9, gene name: MMP9, also named as CLG4B, GELB, MANDP2, MMP-9. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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