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Anti-PMVK monoclonal antibody
Pre-made anti-PMVK monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PMVK/PMVK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T53892-Ab-1/ GM-Tg-hg-T53892-Ab-2 | Anti-Human PMVK monoclonal antibody | Human |
| GM-Tg-rg-T53892-Ab-1/ GM-Tg-rg-T53892-Ab-2 | Anti-Rat PMVK monoclonal antibody | Rat |
| GM-Tg-mg-T53892-Ab-1/ GM-Tg-mg-T53892-Ab-2 | Anti-Mouse PMVK monoclonal antibody | Mouse |
| GM-Tg-cynog-T53892-Ab-1/ GM-Tg-cynog-T53892-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PMVK monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T53892-Ab-1/ GM-Tg-felg-T53892-Ab-2 | Anti-Feline PMVK monoclonal antibody | Feline |
| GM-Tg-cang-T53892-Ab-1/ GM-Tg-cang-T53892-Ab-2 | Anti-Canine PMVK monoclonal antibody | Canine |
| GM-Tg-bovg-T53892-Ab-1/ GM-Tg-bovg-T53892-Ab-2 | Anti-Bovine PMVK monoclonal antibody | Bovine |
| GM-Tg-equg-T53892-Ab-1/ GM-Tg-equg-T53892-Ab-2 | Anti-Equine PMVK monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T53892-Ab-1/ GM-Tg-hg-T53892-Ab-2; GM-Tg-rg-T53892-Ab-1/ GM-Tg-rg-T53892-Ab-2; GM-Tg-mg-T53892-Ab-1/ GM-Tg-mg-T53892-Ab-2; GM-Tg-cynog-T53892-Ab-1/ GM-Tg-cynog-T53892-Ab-2; GM-Tg-felg-T53892-Ab-1/ GM-Tg-felg-T53892-Ab-2; GM-Tg-cang-T53892-Ab-1/ GM-Tg-cang-T53892-Ab-2; GM-Tg-bovg-T53892-Ab-1/ GM-Tg-bovg-T53892-Ab-2; GM-Tg-equg-T53892-Ab-1/ GM-Tg-equg-T53892-Ab-2 |
| Products Name | Anti-PMVK monoclonal antibody |
| Format | mab |
| Target Name | PMVK |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PMVK monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T53892-Ag-1 | Recombinant multi-species PMVK/ HUMPMKI/ PMK protein |
| ORF Viral Vector | pGMLP004314 | human PMVK Lentivirus plasmid |
| ORF Viral Vector | vGMLP004314 | human PMVK Lentivirus particle |
| ORF Viral Vector | pGMLPm004150 | mouse Pmvk Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004150 | mouse Pmvk Lentivirus particle |
Target information
| Target ID | GM-T53892 |
| Target Name | PMVK |
| Gene ID | 10654,68603,310645,717014,612251,101096787,513533,100062963 |
| Gene Symbol and Synonyms | 1110011E12Rik,2900002L22Rik,HUMPMKI,PMK,PMKA,PMKASE,PMVK,POROK1 |
| Uniprot Accession | Q15126,Q2KIU2 |
| Uniprot Entry Name | PMVK_HUMAN,PMVK_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000163344 |
| Target Classification | N/A |
The target: PMVK, gene name: PMVK, also named as HUMPMKI, PMK, PMKA, PMKASE, POROK1. This gene encodes a peroxisomal enzyme that is a member of the galactokinase, homoserine kinase, mevalonate kinase, and phosphomevalonate kinase (GHMP) family of ATP-dependent enzymes. The encoded protein catalyzes the conversion of mevalonate 5-phosphate to mevalonate 5-diphosphate, which is the fifth step in the mevalonate pathway of isoprenoid biosynthesis. Mutations in this gene are linked to certain types of porokeratosis including disseminated superficial porokeratosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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