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Anti-TGFR1/ TGFBR1/ AAT5 monoclonal antibody
Anti-TGFR1/ TGFBR1/ AAT5 antibody for FACS & in-vivo assay
Go to TGFBR1/TGFBR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T53389-Ab-1/ GM-Tg-hg-T53389-Ab-2 | Anti-Human TGFBR1 monoclonal antibody | Human |
| GM-Tg-rg-T53389-Ab-1/ GM-Tg-rg-T53389-Ab-2 | Anti-Rat TGFBR1 monoclonal antibody | Rat |
| GM-Tg-mg-T53389-Ab-1/ GM-Tg-mg-T53389-Ab-2 | Anti-Mouse TGFBR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T53389-Ab-1/ GM-Tg-cynog-T53389-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TGFBR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T53389-Ab-1/ GM-Tg-felg-T53389-Ab-2 | Anti-Feline TGFBR1 monoclonal antibody | Feline |
| GM-Tg-cang-T53389-Ab-1/ GM-Tg-cang-T53389-Ab-2 | Anti-Canine TGFBR1 monoclonal antibody | Canine |
| GM-Tg-bovg-T53389-Ab-1/ GM-Tg-bovg-T53389-Ab-2 | Anti-Bovine TGFBR1 monoclonal antibody | Bovine |
| GM-Tg-equg-T53389-Ab-1/ GM-Tg-equg-T53389-Ab-2 | Anti-Equine TGFBR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T53389-Ab-1/ GM-Tg-hg-T53389-Ab-2; GM-Tg-rg-T53389-Ab-1/ GM-Tg-rg-T53389-Ab-2; GM-Tg-mg-T53389-Ab-1/ GM-Tg-mg-T53389-Ab-2; GM-Tg-cynog-T53389-Ab-1/ GM-Tg-cynog-T53389-Ab-2; GM-Tg-felg-T53389-Ab-1/ GM-Tg-felg-T53389-Ab-2; GM-Tg-cang-T53389-Ab-1/ GM-Tg-cang-T53389-Ab-2; GM-Tg-bovg-T53389-Ab-1/ GM-Tg-bovg-T53389-Ab-2; GM-Tg-equg-T53389-Ab-1/ GM-Tg-equg-T53389-Ab-2 |
| Products Name | Anti-TGFBR1 monoclonal antibody |
| Format | mab |
| Target Name | TGFBR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TGFBR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TGFR1/ TGFBR1/ AAT5 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T53389-Ag-1 | transforming growth factor, beta receptor 1 (TGFBR1) protein |
| ORF Viral Vector | pGMLP001434 | human TGFBR1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001434 | human TGFBR1 Lentivirus particle |
Target information
| Target ID | GM-T53389 |
| Target Name | TGFBR1 |
| Gene ID | 7046,21812,29591,714952,481628,101094057,282382,100034117 |
| Gene Symbol and Synonyms | AAT5,ACVRLK4,ALK-5,ALK5,ESK2,ESS1,LDS1,LDS1A,LDS2A,MSSE,SKR4,tbetaR-I,TbetaRI,TBR-i,TBRI,TGFBR1,TGFR-1 |
| Uniprot Accession | P36897,P80204,O46680 |
| Uniprot Entry Name | TGFR1_HUMAN,TGFR1_RAT,TGFR1_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000106799 |
| Target Classification | Checkpoint-Immuno Oncology, Kinase, Tumor-associated antigen (TAA) |
The target: TGFBR1, gene name: TGFBR1, also named as AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, TBR-i, TBRI, TGFR-1, tbetaR-I. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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