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Anti-EHMT2/ BAT8/ C6orf30 functional antibody
Anti-EHMT2/ BAT8/ C6orf30 functional antibody for cell culture, ELISA & in-vivo assay
Go to EHMT2/EHMT2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T53251-Ab-1/ GM-Tg-hg-T53251-Ab-2 | Anti-Human EHMT2 monoclonal antibody | Human |
| GM-Tg-rg-T53251-Ab-1/ GM-Tg-rg-T53251-Ab-2 | Anti-Rat EHMT2 monoclonal antibody | Rat |
| GM-Tg-mg-T53251-Ab-1/ GM-Tg-mg-T53251-Ab-2 | Anti-Mouse EHMT2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T53251-Ab-1/ GM-Tg-cynog-T53251-Ab-2 | Anti-Cynomolgus/ Rhesus macaque EHMT2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T53251-Ab-1/ GM-Tg-felg-T53251-Ab-2 | Anti-Feline EHMT2 monoclonal antibody | Feline |
| GM-Tg-cang-T53251-Ab-1/ GM-Tg-cang-T53251-Ab-2 | Anti-Canine EHMT2 monoclonal antibody | Canine |
| GM-Tg-bovg-T53251-Ab-1/ GM-Tg-bovg-T53251-Ab-2 | Anti-Bovine EHMT2 monoclonal antibody | Bovine |
| GM-Tg-equg-T53251-Ab-1/ GM-Tg-equg-T53251-Ab-2 | Anti-Equine EHMT2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T53251-Ab-1/ GM-Tg-hg-T53251-Ab-2; GM-Tg-rg-T53251-Ab-1/ GM-Tg-rg-T53251-Ab-2; GM-Tg-mg-T53251-Ab-1/ GM-Tg-mg-T53251-Ab-2; GM-Tg-cynog-T53251-Ab-1/ GM-Tg-cynog-T53251-Ab-2; GM-Tg-felg-T53251-Ab-1/ GM-Tg-felg-T53251-Ab-2; GM-Tg-cang-T53251-Ab-1/ GM-Tg-cang-T53251-Ab-2; GM-Tg-bovg-T53251-Ab-1/ GM-Tg-bovg-T53251-Ab-2; GM-Tg-equg-T53251-Ab-1/ GM-Tg-equg-T53251-Ab-2 |
| Products Name | Anti-EHMT2 monoclonal antibody |
| Format | mab |
| Target Name | EHMT2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-EHMT2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T53251-Ag-1 | Recombinant multi-species EHMT2/ BAT8/ C6orf30 protein |
| ORF Viral Vector | vGMAD000433 | human EHMT2 Adenovirus particle |
| ORF Viral Vector | vGMAD000109 | human EHMT2 Adenovirus particle |
| ORF Viral Vector | pGMAD000433 | human EHMT2 Adenovirus plasmid |
| ORF Viral Vector | pGMAD000109 | human EHMT2 Adenovirus plasmid |
Target information
| Target ID | GM-T53251 |
| Target Name | EHMT2 |
| Gene ID | 10919,110147,361798,715824,474851,101091940,514062,100059118 |
| Gene Symbol and Synonyms | BAT8,C6orf30,D17Ertd710e,EHMT2,G9A,GAT8,KMT1C,NG36 |
| Uniprot Accession | Q96KQ7 |
| Uniprot Entry Name | EHMT2_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000204371 |
| Target Classification | Epigenetic |
The target: EHMT2, gene name: EHMT2, also named as BAT8, C6orf30, G9A, GAT8, KMT1C, NG36. This gene encodes a methyltransferase that methylates lysine residues of histone H3. Methylation of H3 at lysine 9 by this protein results in recruitment of additional epigenetic regulators and repression of transcription. This gene was initially thought to be two different genes, NG36 and G9a, adjacent to each other in the HLA locus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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