Anti-TNR1B/ TNF-R2/ TNFRSF1B monoclonal antibody

Anti-TNR1B/ TNF-R2/ TNFRSF1B antibody for FACS & in-vivo assay

Target products collectionGo to TNF-R2/TNFRSF1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T53033-Ab-1/ GM-Tg-hg-T53033-Ab-2Anti-Human TNF-R2/TNFRSF1B monoclonal antibodyHuman
GM-Tg-rg-T53033-Ab-1/ GM-Tg-rg-T53033-Ab-2Anti-Rat TNF-R2/TNFRSF1B monoclonal antibodyRat
GM-Tg-mg-T53033-Ab-1/ GM-Tg-mg-T53033-Ab-2Anti-Mouse TNF-R2/TNFRSF1B monoclonal antibodyMouse
GM-Tg-cynog-T53033-Ab-1/ GM-Tg-cynog-T53033-Ab-2Anti-Cynomolgus/ Rhesus macaque TNF-R2/TNFRSF1B monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T53033-Ab-1/ GM-Tg-felg-T53033-Ab-2Anti-Feline TNF-R2/TNFRSF1B monoclonal antibodyFeline
GM-Tg-cang-T53033-Ab-1/ GM-Tg-cang-T53033-Ab-2Anti-Canine TNF-R2/TNFRSF1B monoclonal antibodyCanine
GM-Tg-bovg-T53033-Ab-1/ GM-Tg-bovg-T53033-Ab-2Anti-Bovine TNF-R2/TNFRSF1B monoclonal antibodyBovine
GM-Tg-equg-T53033-Ab-1/ GM-Tg-equg-T53033-Ab-2Anti-Equine TNF-R2/TNFRSF1B monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T53033-Ab-1/ GM-Tg-hg-T53033-Ab-2; GM-Tg-rg-T53033-Ab-1/ GM-Tg-rg-T53033-Ab-2;
GM-Tg-mg-T53033-Ab-1/ GM-Tg-mg-T53033-Ab-2; GM-Tg-cynog-T53033-Ab-1/ GM-Tg-cynog-T53033-Ab-2;
GM-Tg-felg-T53033-Ab-1/ GM-Tg-felg-T53033-Ab-2; GM-Tg-cang-T53033-Ab-1/ GM-Tg-cang-T53033-Ab-2;
GM-Tg-bovg-T53033-Ab-1/ GM-Tg-bovg-T53033-Ab-2; GM-Tg-equg-T53033-Ab-1/ GM-Tg-equg-T53033-Ab-2
Products NameAnti-TNF-R2/TNFRSF1B monoclonal antibody
Formatmab
Target NameTNF-R2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TNF-R2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TNR1B/ TNF-R2/ TNFRSF1B VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T53033-Ag-1tumor necrosis factor receptor superfamily, member 1B (TNFRSF1B) protein
    ORF Viral VectorvGMAP000424Human TNFRSF1B Adenovirus particle
    ORF Viral VectorpGMAP000424Human TNFRSF1B Adenovirus plasmid
    ORF Viral VectorpGMLPm002568mouse Tnfrsf1b Lentivirus plasmid
    ORF Viral VectorpGMLPm005448mouse Tnfrsf1b Lentivirus plasmid
    ORF Viral VectorvGMLPm002568mouse Tnfrsf1b Lentivirus particle
    ORF Viral VectorvGMLPm005448mouse Tnfrsf1b Lentivirus particle


    Target information

    Target IDGM-T53033
    Target NameTNF-R2
    Gene ID7133,21938,156767,715454,487437,101080392,338033,100055840
    Gene Symbol and SynonymsCD120b,p75,p75TNFR,TBPII,TNF-alphaR2,TNF-R-II,TNF-R2,TNF-R75,TNF-RII/TNFRSF1B,TNFalpha-R2,TNFBR,Tnfr-1,TNFR1B,TNFR2,TNFR80,TNFRII,TNFRSF1B
    Uniprot AccessionP20333,Q80WY6
    Uniprot Entry NameTNR1B_HUMAN,TNR1B_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, Cytokine Target
    DiseaseOvary Cancer
    Gene EnsemblENSG00000028137
    Target ClassificationCheckpoint-Immuno Oncology

    The target: TNF-R2, gene name: TNFRSF1B, also named as CD120b, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR2, TNFR80, p75, p75TNFR. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.