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Anti-CRY2/ HCRY2/ PHLL2 functional antibody
Anti-CRY2/ HCRY2/ PHLL2 functional antibody for cell culture, ELISA & in-vivo assay
Go to CRY2/CRY2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T51908-Ab-1/ GM-Tg-hg-T51908-Ab-2 | Anti-Human CRY2 monoclonal antibody | Human |
| GM-Tg-rg-T51908-Ab-1/ GM-Tg-rg-T51908-Ab-2 | Anti-Rat CRY2 monoclonal antibody | Rat |
| GM-Tg-mg-T51908-Ab-1/ GM-Tg-mg-T51908-Ab-2 | Anti-Mouse CRY2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T51908-Ab-1/ GM-Tg-cynog-T51908-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CRY2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T51908-Ab-1/ GM-Tg-felg-T51908-Ab-2 | Anti-Feline CRY2 monoclonal antibody | Feline |
| GM-Tg-cang-T51908-Ab-1/ GM-Tg-cang-T51908-Ab-2 | Anti-Canine CRY2 monoclonal antibody | Canine |
| GM-Tg-bovg-T51908-Ab-1/ GM-Tg-bovg-T51908-Ab-2 | Anti-Bovine CRY2 monoclonal antibody | Bovine |
| GM-Tg-equg-T51908-Ab-1/ GM-Tg-equg-T51908-Ab-2 | Anti-Equine CRY2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T51908-Ab-1/ GM-Tg-hg-T51908-Ab-2; GM-Tg-rg-T51908-Ab-1/ GM-Tg-rg-T51908-Ab-2; GM-Tg-mg-T51908-Ab-1/ GM-Tg-mg-T51908-Ab-2; GM-Tg-cynog-T51908-Ab-1/ GM-Tg-cynog-T51908-Ab-2; GM-Tg-felg-T51908-Ab-1/ GM-Tg-felg-T51908-Ab-2; GM-Tg-cang-T51908-Ab-1/ GM-Tg-cang-T51908-Ab-2; GM-Tg-bovg-T51908-Ab-1/ GM-Tg-bovg-T51908-Ab-2; GM-Tg-equg-T51908-Ab-1/ GM-Tg-equg-T51908-Ab-2 |
| Products Name | Anti-CRY2 monoclonal antibody |
| Format | mab |
| Target Name | CRY2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CRY2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T51908-Ag-1 | Recombinant multi-species CRY2/ HCRY2/ PHLL2 protein |
| ORF Viral Vector | pGMLV000074 | human CRY2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000074 | human CRY2 Lentivirus particle |
| ORF Viral Vector | pGMLPm005230 | mouse Cry2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005230 | mouse Cry2 Lentivirus particle |
Target information
| Target ID | GM-T51908 |
| Target Name | CRY2 |
| Gene ID | 1408,12953,170917,715000,483641,101084825,509058,100056637 |
| Gene Symbol and Synonyms | CRY2,D130054K12Rik,HCRY2,PHLL2 |
| Uniprot Accession | Q49AN0,Q923I8 |
| Uniprot Entry Name | CRY2_HUMAN,CRY2_RAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000121671 |
| Target Classification | N/A |
The target: CRY2, gene name: CRY2, also named as HCRY2, PHLL2. This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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