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Anti-ROCK1 monoclonal antibody
Pre-made anti-ROCK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ROCK1/ROCK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T51282-Ab-1/ GM-Tg-hg-T51282-Ab-2 | Anti-Human ROCK1 monoclonal antibody | Human |
| GM-Tg-rg-T51282-Ab-1/ GM-Tg-rg-T51282-Ab-2 | Anti-Rat ROCK1 monoclonal antibody | Rat |
| GM-Tg-mg-T51282-Ab-1/ GM-Tg-mg-T51282-Ab-2 | Anti-Mouse ROCK1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T51282-Ab-1/ GM-Tg-cynog-T51282-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ROCK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T51282-Ab-1/ GM-Tg-felg-T51282-Ab-2 | Anti-Feline ROCK1 monoclonal antibody | Feline |
| GM-Tg-cang-T51282-Ab-1/ GM-Tg-cang-T51282-Ab-2 | Anti-Canine ROCK1 monoclonal antibody | Canine |
| GM-Tg-bovg-T51282-Ab-1/ GM-Tg-bovg-T51282-Ab-2 | Anti-Bovine ROCK1 monoclonal antibody | Bovine |
| GM-Tg-equg-T51282-Ab-1/ GM-Tg-equg-T51282-Ab-2 | Anti-Equine ROCK1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T51282-Ab-1/ GM-Tg-hg-T51282-Ab-2; GM-Tg-rg-T51282-Ab-1/ GM-Tg-rg-T51282-Ab-2; GM-Tg-mg-T51282-Ab-1/ GM-Tg-mg-T51282-Ab-2; GM-Tg-cynog-T51282-Ab-1/ GM-Tg-cynog-T51282-Ab-2; GM-Tg-felg-T51282-Ab-1/ GM-Tg-felg-T51282-Ab-2; GM-Tg-cang-T51282-Ab-1/ GM-Tg-cang-T51282-Ab-2; GM-Tg-bovg-T51282-Ab-1/ GM-Tg-bovg-T51282-Ab-2; GM-Tg-equg-T51282-Ab-1/ GM-Tg-equg-T51282-Ab-2 |
| Products Name | Anti-ROCK1 monoclonal antibody |
| Format | mab |
| Target Name | ROCK1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-ROCK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T51282-Ag-1 | Recombinant multi-species ROCK1/ P160ROCK/ ROCK-I protein |
| ORF Viral Vector | vGMLV000212 | human ROCK1 Lentivirus particle |
| ORF Viral Vector | pGMLV000212 | human ROCK1 Lentivirus plasmid |
Target information
| Target ID | GM-T51282 |
| Target Name | ROCK1 |
| Gene ID | 6093,19877,81762,698223,480181,101092552,785911,100034056 |
| Gene Symbol and Synonyms | 1110055K06Rik,P160ROCK,ROCK-I,ROCK1 |
| Uniprot Accession | Q13464,Q63644,Q8MIT6 |
| Uniprot Entry Name | ROCK1_HUMAN,ROCK1_RAT,ROCK1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000067900 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: ROCK1, gene name: ROCK1, also named as P160ROCK, ROCK-I. This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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